Syhthesis, Characterization and Antimicrobial Studies of Isatin Thiosemicarbazones Derivatives of Dichlorobis(cyclopentadienyl) hafnium(IV)


  • Kushal Nath Mishra
  • Om Prakash Pandey
  • S K Sengupta
  • Shambaditya Goswami Asst Professor ITM,GIDA Gorakhpur, Uttar Pradesh


Cp2HfCl2, Thiosemicarbazones, IPTSH, IMTSH, Antimicrobial activity


The reactions of Cp2HfCl2, with thiosemicarbazones (LH) derived from isatin and 4-nitrophenyl substituted (IPTSH) and 4-methyl phenyl substituted (IMTSH) thiosemicarbazide in various stoichiometric rations have been studied and the complexes of the type [Cp2HfCl(L)] and [Cp2Hf(L)3] are obtained. Tentative structural conclusions are drawn for the reaction products based upon elemental analyses, electrical conductance, magnetic moment and (UV-Vis, IR, 1H NMR and 13C NMR) spectral data. Gram positive, gram negative bacteria and unicellular, multicellular fungi have been used for the evaluation of antimicrobial activity with selected antibiotics for the comparison. 4-Nitro Phenyl substituted moiety exhibited promising antibacterial and antifungal activities.

Author Biography

Shambaditya Goswami, Asst Professor ITM,GIDA Gorakhpur, Uttar Pradesh

Pharmaceutical Chemistry



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How to Cite

Mishra, K. N., Pandey, O. P., Sengupta, S. K., & Goswami, S. (2015). Syhthesis, Characterization and Antimicrobial Studies of Isatin Thiosemicarbazones Derivatives of Dichlorobis(cyclopentadienyl) hafnium(IV). Asian Journal of Applied Sciences, 3(3). Retrieved from