Comparision and Extract Hypoglycemic Activity Root Extract Tablet Cats (Acalypha Indica Linn) Mice the White Male Strain Ddy
Keywords:
Acalyphaindica, hypoglycemic activity, Extract TabletAbstract
The study concerning to the comparison of hypoglycemic activity of the extract and Acalypha indica Linn. Tablet in mice male ddy strain that has been conducted . The purpose of this study is to compare the hypoglycemic activity of the leaf, herb and root extract and it’s tablets between pure extracts and extract tablets . Mice were divided into 8 groups, namely Normal Controls (KN), Glibenclamide (G) Leaf Extract (ED), Herbal Extract (EH), Root Extract (EA), Tablets Leaf Extract (TD), Herbal Extract Tablets (TH), and Tablet Root Extract (TA). Measurement of blood glucose level performed at 4 time points; fasting blood sugar (T0), 30 minutes after the test material (T30), 30 min after glucose administration ( T30 pc) and 2 hours after glucose administration/post prandial (T120 pc). The results showed that the group of ED and EA, and TD and TH have hypoglycemic effects that differ significantly by group KN. EH and TA group had hypoglycemic effects that did not differ significantly by group KN. ED had significantly different hypoglycemic activity with EH and EA. There is no significant differences between the hypoglycemic activity of the tablets extract for all grups. Herb extract had significantly different hypoglycemic activity with it’s tablets.
References
Anonim, 2008. Tingkat Manfaat Keamanan dan Efektifitas Tanaman Obat dan Obat
Tradisional. Balai Besar Penelitian dan Pengembangan Tanaman Obat dan Obat Tradisional.
Badan Penelitian dan Pengembangan Kesehatan Departemen Kesehatan RI (in Indonesia
Language) .
Gopalakrishnan V, 2000. Antimicrobial Activity of Extrats of Acalypha indica Linn, College
of Pharmacy Sri Ramachandra College and Research Institute (Deemed University) Poror,
Chennai – 600116
Govindarajan M., et al., 2008. Antibacterial Activity o Acalypha indica L. European Review
for Medical and Pharmacological Sciences. 12, p. 299-302.
Murugan T dan Saranraj P., 2011. Antibacterial Activity of Various Solvent Extract of The
Indian Herbal Plant Acalypha indica Against Human Patogens Causing Nasocomial
Infection. International Journal of Pharmaceutical and Biological Archives: 2(5)
p. 1473-1478
Thenmozhi S dan Rajan S., 2012. Screening of Antibacterial and Phytochemical Activity of
Acalypha indica Linn. Against Isolated Respiratory Pathogens. Research in Plant Biology.
(1). p.01-06
Prihandini K, 2004. Pengaruh Pemberian Rebusan Akar Acalypha indica Linn. (Akar
Kucing Secara Oral Terhadap Kadar Asam Urat Darah Tikus Putih Jantan Yang Diinduksi
dengan Kafein. Skripsi Sarjana, Departemen Farmasi FMIPA UI (in Indonesia
Language) , Depok, Indonesia.
Pratita A, 2004. Pengaruh Rebusan Akar Tanaman Akar Kucing (Acalypha indica Linn.)
Terhadap Kadar Asam Urat Dalam Darah pada Tikus Putih Jantan Yang Diinduksi Kalium
Oksonat. Skripsi Sarjana, Departemen Farmasi FMIPA UI (in Indonesia Language), Depok.
Hartanto MD, 2006. Pengaruh Sari Fraksi Heksana, Kloroform, Etil Asetat dan Sisa Air
dari Rebusan Akar Tanaman Akar Kucing (Acalypha indica Linn.) Dosis 10,8 g/200g BB
Terhadap Kadar Asam Urat Dalam Darah Tikus Putih Jantan Yang Diinduksi Kalium
Oksonat. Skripsi Sarjana, Departemen Farmasi FMIPA UI (in Indonesia Language) , Depok.
Dwijayanto B, 2006. Pengaruh beberapa Fraksi Rebusan Akar Acalypha indica Linn. Dosis
Setara Akar Kucing 5,4 g/200 g BB Terhadap Kadar asam Urat Dalam Darah Tikus Putih
Jantan Yang Diinduksi Kalium Oksonat. Skripsi Sarjana. Departemen Farmasi FMIPA UI (in
Indonesia Language), Depok, Indonesia.
Ahmed A.K, 2005. Diuretic Activity of Acalypha indica. Dhaka University, Journal of
Pharmaceutical Science Vo. 4 No. 1 June.
Rajathi M. D, et al, 2012. Antidiabetic and antimicrobial activity of Acalypha indica Linn.
Extract. Journal of Scientific Research in Pharmacy, 1 (3).
Saha R., Ahmed A, 2011. Hypoglycemic Effect of Acalypha indica Linn Ekxtract on
Streptozotocin Induced Diabetes in Rat. International Journal of Pharmaceutical Sciences
and Research, Vol 2, Issue 11
Manisha M., et al, 2011. Antidiabetic Activity of Acalypha indica Linn. On Normal and
Alloxan Induced Diabetic Rats. International Journal of Pharmacy and Pharmaceutical
Sciences, Vol.3 (3).
Ocktarini R, 2010. Pengaruh Ekstrak Herba anting-anting (Acalypha australis L)
Terhadap Kadar Glukosa Darah Mencit Balb/C Induksi Streptozotocin (in Indonesia
Language) . Skripsi Fakultas Kedokteran Sebelas Maret Surakarta, Indonesia.
Purwaningsih E.H. et al, 2008. Neuro-protection and Neuro-therapy effect of Acalypha
indica Linn. Water Extract Ex Vivo on Musculus gastrocnemius Frog. Makara Kesehatan,
Vol. 12 No. 2: 71-76, Depok, Indonesia
Felicia., 2009. Efek Neuroterapi Ekstrak Air akar Acalypha indica Linn (Akar Kucing)
Dosis 20 mg dan 25 mg Secara Eks Vivo Pada Saraf Otot Gastroknemius Katak. Fakultas
Kedokteran Universitas Indonesia. Jakarta, Indonesia.
Junaedi, et. al., 2013. Formulasi Tablet Ekstrak Rebusan Akar, Daunt dan Herba Akar
Kucing (Acalypha indica Linn.) Dengan Metode Cetak Langsung (in Indonesian
Language) . Karya Tulis Ilmiah. Poltekkes Kemenkes Jakarta II Jurusan Farmasi, Jakarta.
Anonim, 2000. Parameter Standar Umum Ekstrak Tumbuhan Obat. Direktorat Jendral
Pengawasan Obat dan Makanan, Departemen Kesehatan Republik Indonesia Jakarta.
Ansel H.C, 2005. Pengantar Bentuk Sediaan Farmasi edisi keempat. Penerbit Universitas
Indonesia, Jakarta, Indonesia.
Siregar, C, “Pharmaceutical preparations tablet technology, Practical Basics†(in
Indonesian Language), pp 129-153, 163, 515, 2010.
Hutapea J.R, 1993. Inventaris Tanaman Obat Indonesia (II), Departemen Kesehatan
Republik Indonesia, Jakarta, Indonesia.
Simalango R, 2003. Analisis Pendahuluan Kandungan Kimia Akar dan Herba Serta Pola
Kromatogram Fraksi Etanol Ekstrak N – Heksana Herba Acalypha indica Linn. Yang
Tumbuh di Depok. Skripsi Sarjana, Departemen Farmasi FMIPA UI, Depok.
Susanti S, 2006. Isolasi dan Identifikasi Senyawa-senyawa Kimia Fraksi N – Heksana dan
Etil Asetat dari Ekstrak Etanol Akar Tanaman Acalypha indica Linn. (Akar Kucing).
Skripsi Sarjana, Departemen Farmasi FMIPA UI, Depok, Indoneisa.
Duke J., 2006. Phytochemical and Database.
http://www.ars-grin.gov/duke/onlinedatabase/acalypha indica L/listofchemical html.
Saha R., Ahmed, A, 2011. Phytochemical Constituent and Pharmacological activities
of Acalypha indica Linn. International Journal of Pharmacy and Pharmaceutical Sciences,
Vol 2 (8) : 1900-1904
Anonim, 1993, Penapisan Farmakologi, Pengujian Fitokimia dan Pengujian Klinik,
Yayasan Pengembangan Obat Bahan Alam Phyto Medika, Jakarta, Indonesia.
Downloads
Published
How to Cite
Issue
Section
License
- Papers must be submitted on the understanding that they have not been published elsewhere (except in the form of an abstract or as part of a published lecture, review, or thesis) and are not currently under consideration by another journal published by any other publisher.
- It is also the authors responsibility to ensure that the articles emanating from a particular source are submitted with the necessary approval.
- The authors warrant that the paper is original and that he/she is the author of the paper, except for material that is clearly identified as to its original source, with permission notices from the copyright owners where required.
- The authors ensure that all the references carefully and they are accurate in the text as well as in the list of references (and vice versa).
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Attribution-NonCommercial 4.0 International that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
- The journal/publisher is not responsible for subsequent uses of the work. It is the author's responsibility to bring an infringement action if so desired by the author.