The Correlation between the Levels of Troponin I with the Amount of Leukocytes in Patients Suspected Acute Myocardial Infarction

Authors

  • Tri Prasetyorini MEDICAL TECHNOLOGY LABORATORY POLYTECHNIC HEALTH
  • Rizka Noviyanti MEDICAL TECHNOLOGY LABORATORY POLYTECHNIC HEALTH
  • Putu Puja Permata Kasih MEDICAL TECHNOLOGY LABORATORY POLYTECHNIC HEALTH
  • Diah Lestari MEDICAL TECHNOLOGY LABORATORY POLYTECHNIC HEALTH

DOI:

https://doi.org/10.24203/ajas.v7i1.5724

Keywords:

Acute Myocardial Infarction (AMI), Troponin I, leukocyte

Abstract

Acute Myocardial Infarction (AMI) is a manifestation of acute myocardial ischemia and is generally caused by the rupture of atherosclerosis and thrombus in the coronary blood vessels. Rupture causes an inflammatory process that leukocytes which acts as a marker of inflammation increases. Heart muscle damage that occurs also resulted in levels of troponin I as one of the markers of increased cardiac examination. Based on that research aims to determine the correlation between the levels of troponin I and the number of leukocytes in patients with suspected AMI.This research method is analytical observation with a data sample of 100 patients with suspected AMI diagnosis by doctors as well as examine the levels of troponin I and the number of leukocytes in dr. Abdulmadjid Chasbullah Bekasi. The correlation between the levels of troponin I and leukocyte counts were analyzed using Spearman's test. Data studied consisted of 52 people (52%) men and 48 (48%) of women. By age group, age range 46-65 years become the largest age group into patients with suspected AMI is 55 people (55%). Obtained 34 (34%) of patients with suspected AMI who had higher levels of troponin I and normal leukocyte count, and 39 (39%) of patients with suspected AMI who had troponin I levels and elevated leukocyte count. On Spearman’s test seen the correlation between levels of troponin I with the total of leukocytes in patients with suspected AMI (p = 0.000 and r = 0.50). This shows an increase in troponin I, which runs parallel with the increase in the total of leukocytes. Suggested for further research to see the difference increased levels of troponin I and the total of leukocytes between 3-5 hours and 14-18 hours after myocardial injury

References

KementerianKesehatan RI. PenyakitJantungPenyebabKematianTertinggi, KemenkesIngatkan CERDIK. Biro KomunikasidanPelayananMasyarakat,KementerianKesehatan RI. Cited Maret 2017.From :http://www.depkes.go.id/article/view/17073100005/penyakit-jantung-penyebab-kematian-tertinggi-kemenkes-ingatkan-cerdik-.html, 2017.

Majid, A., PenyakitJantungKoroner, Patofisiologi, Pencegahan, danPengobatanTerkini, JurnalPenelitian, FakultasKedokteranUniversitas Sumatera Utara, Medan, 2007.

PerhimpunanDokterSpesialisKardiovaskuler Indonesia (PERKI), PedomanTatalaksanaSindromKoronerAkutEdisiKetiga. Centra Communications, 2015

Kumar V, Abbas AK, Aster JC. BukuAjarPatologi Robbins. Vol. 2. Ed. 9..Elsevier.Singapura.hh. 329-334, 2015.

Aoronson PI, Ward JP. At a glance SistemKardiovaskular. 3rd Edition.Erlangga. Jakarta. p. 94-95, 2008.

Kosasih, E.N., PemeriksaanLaboratoriumKlinik, KARISMA Publishing Group, Tangerang, 2008.

Samsu, N., Sargowo, D., SensitivitasdanSpesifisitas Troponin T dan I pada Diagnosis InfarkMiokardAkut, MajalahKedokteran Indonesia, FakultasKedokteranUnversitasBrawijaya, Malang, 2007.

Grzybowski M, Welch RD, Parsons L, Ndumele CE, Chen E, Zalenski R, et al. The association between WBC and AMI in hospital mortality: findings from the National Registry of Myocardial Infarction. Academic Emergency Medicine.Vol. 11(10).hh: 1049-60, 2004.

Price SA, Wilson LM.. Patofisiologi. In: Pendit BU, Hartanto H, Wulansari P, Mahanani DA, transl. KonsepKlinis Proses-proses Penyakit Vol 1 (6th ed). EGC. Jakarta, 2005.

Núñez JE, Núñez E, Bertomeu V, et al. Prognostic value of baseline white blood cell count in patients with acute myocardial infarction and ST segment elevation.Heart.Vol. 91(8).hh.1094-1095, 2005.

Jee, et al., White Blood Cell Count and Risk for All Cause, Cardiovascular, and Cancer Mortality in a Cohort of Koreans. American Journal of Epidemiology , 2005.

Sitepu, Ade M. Djafar, Dewi U. Panda, Agnes L. GambaranJumlahLeukositpadaPasienInfarkMiokardAkut di RSUP Prof. Dr. R. D. Kandou Manado PeriodeJanuari-Desember 2015.Vol. 4 (2).Jurnal e-Clinic (eCl), 2016.

Maison M.. PerananLeukositosisSebagaiUjiDiagnostikTambahPadaPenderitaInfarkMiokardAkut. UniversitasDiponegoro. Semarang, 2000.

Meidhiyanto, Radiyan. Uddin, Ilham. Sofia, SefriNoventi. HubunganJumlahLeukositTerhadap Kadar Troponin I padaPasienInfarkMiokard. Vol. 5 (4).JurnalKedokteranDiponegoro. 2016.

Carbone, F. et al., Pathophysiological role of neutrophils in acute myocardial infarction.ThrombHaemost, 2013.

Septiana, A.S.,.KorelasiAktivitas CK-MB dan Kadar Troponin I padaPasienSuspek PJK di RSPAD GatotSoebroto.KaryaTulisIlmiah. JurusanAnalisKesehatan. PoltekkesKemenkes Jakarta III, 2017.

Rafieian-Kopaei, M., Setorki, M., Doudi, M., Baradaran, A., Nasri, H. Atherosclerosis : Process, Indicators, Risk Factors and New Hopes. Vol. 5 (8).International Journal of Preventive Medicine, 2014.

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Published

2019-03-17

How to Cite

Prasetyorini, T., Noviyanti, R., Permata Kasih, P. P., & Lestari, D. (2019). The Correlation between the Levels of Troponin I with the Amount of Leukocytes in Patients Suspected Acute Myocardial Infarction. Asian Journal of Applied Sciences, 7(1). https://doi.org/10.24203/ajas.v7i1.5724

Issue

Vol. 7 No. 1 (2019): February 2019

Section

Articles

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