Chemical Constituents of the Leaf Essential Oil of Physalis angulata L.
Keywords:
Physalis angulata, essential oil composition, phytol, hexahydrofarnesyl acetoneAbstract
This paper report the chemical constituents identified in the essential oil obtained from the leaves of Physalis angulata L., grown in Nigeria. The essential oil was obtained by hydrodistillation in an all glass Clevenger-type oil apparatus in the Laboratory, Department of Chemistry, Lagos State University, Ojo, Nigeria. The oil was analysed for its constituents by means of gas chromatography-flame ionization detector (GC-FID) and gas chromatography coupled with mass spectrometry (GC-MS). The main chemical classes identified in the oil were diterpenes (31.7%), fatty acids (22.8%), oxygenated sesquiterpenes (22.3%) and aromatic compounds (13.6%). Monoterpene compounds occurred in trace amounts. The major constituents of the essential oil were phytol (31.7%) and hexahydrofarnesyl acetone or 6,10,14-trimethy-2-pentadecanone (18.8%), with significant amounts of n-nonadecane (8.6%) and n-hexadecanoic acid (5.0%).
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References
Abo, K.A., Lawal, I.O., ‘’Antidiabetic activity of Physalis angulata extracts and fractions in alloxan-induced diabetic rats,’’ Journal of Advances in Scientific Research, vol. 4, no. 3, pp. 2-6, 2013.
Adams, R.P., Identification of Essential Oil Components by Gas Chromatography/Quadrupole Mass Spectrometry, Allured Publishing Corp. Carol Stream, IL, 2007.
Bastos, GNT, Santos, ARS, Ferreira, V.M.M., Costa, A.M.R., Bispo, C.I., Silveira, A.J.A., Do Nascimento, J.L.M., ‘’Antinociceptive effect of the aqueous extract obtained from roots of Physalis angulata L. on mice’’ Journal of Ethnopharmacology, vol. 103, no. 2, pp. 241-245, 2006.
British Pharmacopoeia., HM Stationary Office Vol. II, pp. 109, 1980.
Burkill, H.M., The Useful Plants of West Tropical Africa. Royal Botanical Gardens, Kew, London, pp. 686, 2008.
El Ayeb-Zakhama, A., Salem, S.B., Sakka-Rouis, L., Flamini, G., Jannet, H.B. and Harzallah-Skhiri, F. ‘’Chemical composition and phytotoxic effects of essential oils obtained from Ailanthus altissima (Mill.) Swingle cultivated in Tunisia’’, Chemistry and Biodiversity, vol. 11, no. 18, pp. 1216-1227, 2014.
Gbile, Z.O. and Soladoye, M.O. Vernacular names of Nigerian plants (Yoruba) Vol. 2, FRIN, Ibadan, pp. 101, 2004.
Ismail, N. and Alam, M. ‘’A novel cytotoxic flavonoid glycoside from Physalis angulata’’, Fitoterapia, vol. 72, no. 6, pp. 676-679, 2001.
Januário, A.H., Filho, E.R., Pietro, R.C., Kashima, S., Sato, D.N. and França, S.C. ‘’Antimycobacterial physalins from Physalis angulata L. (Solanaceae),’’ Phytotherapy Research, vol. 16, no. 5, pp. 445-448, 2002.
Lawal, O.A., Ogunwande, I.A., Salvador, A.F., Sanni, A.A. and Opoku, A.R. ‘’Pachira glabra Pasq. Essential oil: chemical constituents, antimicrobial and insecticidal activities’’, Journal of Oleo Science, vol. 63, no. 6, pp. 629-635, 2014.
Li, Y.H., Rao, P.N.P., Habeeb, A.G. and Kanus. E.E. ‘’Design, syntheses, and evaluation of 2,3-diphenylcycloprop-2-en-1-ones and oxime derivatives as potential cyclooxygenase-2 inhibitors with analgesic-anti-inflammatory activity’’, Drug Development Research, vol. 57, no. 1, pp. 6-17, 2002.
Mahalakshmi, A.M. and Ramesh, B.N. ‘’Physalis angulata L.: an ethanopharmacological review’’, Indo American Journal of Pharmaceutical Research, vol. 4, no. 3, pp. 2231-6876, 2014.
Merit, E.R., Zhuang, J., Abraham, J.V., Gerald, B.H. and Paula, J.B. ‘’Physangulidine A, a withanolide from Physalis angulata, perturbs the cell cycle and induces cell death by apoptosis in prostate cancer cells’’, Journal of Natural Product, vol. 76, no. 1, pp. 2-7, 2013.
National Institute of Standards and Technology. Chemistry Web Book. Data from NIST Standard Reference Database 69, 2011, http://www.nist.gov/.
Ogundajo, A.L,, Ogunwande, I.A., Bolarinwa, T.M., Joseph, O.R. and Flamini, G. ‘’ Essential oil from the leaves of Hibiscisus suranthesis L. from Nigeria’’, Journal of Essential Oil Research, vol. 26, no. 2, pp. 114-117, 2014.
Osho, A., Adetunji, T., Fayemi, S.O. and Moronkola, D.O. ‘’Antimicrobial activity of essential oils of Physalis angulata. L’’, African Journal of Traditional and Complementary Alternative Medicine, vol. 7, no. 4, pp. 303-306, 2010.
Radulović, N., Stojanović, G. and Palić, R. ‘’Composition and antimicrobial activity of Equisetum arvense L. essential oil’’, Phytotherapy Research, vol. 20, no. 1, pp. 85-88, 2006.
Razavi, S.M. and Nejad-Ebrahimi, S. ‘’Phytochemical analysis and allelopathic activity of essential oils of Ecballium elaterium A. Richard growing in Iran’’, Natural Product Research, vol. 24, no. 18, pp. 1704-1709, 2010.
Shingu, K., Yahara, S., Okabe, H. and Nohara, T. ‘’Three new withanolides, physagulins E, F and G from Physalis angulata L’’, Chemical and Pharmaceutical Bulletin, vol. 40, no. 9, pp. 2448-2451, 1992.
Shravan, K.N., Kishore, G., Siva, K.G. and Sindhu, P.E.S. ‘’In vitro anti-inflammatory and anti-arthritic activity of leaves of Physalis angulata L’’, International Journal of Pharmaceutical and Industrial Research, vol. 1, no. 3, pp. 211-213, 2011.
Shravan, K.N., Chandramohan, R.G., Sivakumar, G., Sindhu, P.E.S. and Somasekhar, P. ‘’Evaluate in-vitro study on α-amylase inhibitory effect of poly herbal extract of roots of Physalis angulata and barks of Terminalia arjuna’’, International Journal of Advances in Pharmaceutical Research, vol. 2, no. 4, pp. 476-479, 2011.
Shravan, K.N., Kannadhasan, R., Kishore, G., Sivakumar, G. and Somasekhar, P. ‘’Anti-ulcer activity of the ethanolic extract of leaves of Physalis angulata L’’, International Journal of Pharmacy and Pharmaceutical sciences, vol. 4, no. 4, pp. 226-228, 2012.
Soares, M.B., Bellintani, M.C., Ribeiro, I.M., Tomassini, T.C., Ribeiro, D.N. and Santos, R. ‘’Inhibition of macrophage activation and lipopolysaccaride-induced death by seco-steroids purified from Physalis angulata L’’, European Journal of Pharmacology, vol. 459, no. 1, pp. 107-112, 2003.
Velazquez, P.M.D.C., Nogueira, C., De Gustavo, C.D., Eberlin, S., Mussi, L., De Paulo, T.V.E.R. and Polezel, M.A. ‘’Use of Physalis angulata (mullaca/camapú) extract and/or physalins’’. US Patient Number WO 2009095745 A1, 2009.
Yang, M.F., Pan, X.F., Zhao, X.H. and Wang, J.Z. ‘’Study on the chemical constituents of the essential oil of berries of Physalis pubescens’’, Journal of Northeast Forestry University, vol. 24, no. 1, pp. 94-98, 1996.
Yilmaztekin, M. ‘’Analysis of volatile components of Cape Gooseberry (Physalis peruviana L.) grown in Turkey by HS-SPME and GC-MS’’, The Scientific World Journal, 2014, Article ID 796097, pp. 1-8, 2014.
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