Arterial Stiffness in Older People with Different Types of Dementia Compared to Older People without Cognitive Dysfunction

Authors

  • Ahmet Yalcin
  • Volkan Atmis
  • Ozlem Karaarslan Cengiz
  • East Cinar
  • Murat Varli
  • Sevgi Aras
  • Teslime Atli

Keywords:

Dementia, arterial Stiffness, pulse wave velocity, older people

Abstract

Alzheimer’s disease and vascular dementia are the most common causes of cognitive dysfunction among older people. Vascular damage plays a role in the etiopathogenesis of both Alzheimer’s disease and vascular dementia. Arterial stiffness is a marker of vascular damage. The aim of this study was to compare arterial stiffness between Alzheimer’s disease, vascular dementia and controls without memory complaints. A total of 72 older people (Alzheimer’s disease=22, vascular dementia=28, controls=22) were included in the study. Demographic data were obtained and ambulatory blood pressure monitoring was applied. Arterial stiffness was evaluated with carotid to femoral pulse wave velocity measurements. Mean pulse wave velocity was 10.7±2.0 m/s, 11.3±3.1 m/s, and 10.0±3.1 m/s in Alzheimer’s disease, vascular dementia and controls, respectively (p>0.05).Arterial stiffness assessed by pulse wave velocity might play a role in the development of vascular dementia and Alzheimer's disease, but further evidence is needed to confirm this relationship.

References

Hanon O, Haulon S, Lenoir H, Seux ML, Rigaud AS, Safar M, Girerd X, Forette F: Relationship between arterial stiffness and cognitive function in elderly subjects with complaints of memory loss. Stroke; a journal of cerebral circulation 2005, 36(10):2193-2197.

Liu IY, LaCroix AZ, White LR, Kittner SJ, Wolf PA: Cognitive impairment and mortality: a study of possible confounders. American journal of epidemiology 1990, 132(1):136-143.

Weiler PG, Lubben JE, Chi I: Cognitive impairment and hospital use. American journal of public health 1991, 81(9):1153-1157.

Gill TM, Richardson ED, Tinetti ME: Evaluating the risk of dependence in activities of daily living among community-living older adults with mild to moderate cognitive impairment. The journals of gerontology Series A, Biological sciences and medical sciences 1995, 50(5):M235-241.

Suehs BT, Davis CD, Alvir J, van Amerongen D, Pharmd NC, Joshi AV, Faison WE, Shah SN: The clinical and economic burden of newly diagnosed Alzheimer's disease in a medicare advantage population. American journal of Alzheimer's disease and other dementias 2013, 28(4):384-392.

O'Brien JT, Erkinjuntti T, Reisberg B, Roman G, Sawada T, Pantoni L, Bowler JV, Ballard C, DeCarli C, Gorelick PB et al: Vascular cognitive impairment. Lancet neurology 2003, 2(2):89-98.

Pase MP, Herbert A, Grima NA, Pipingas A, O'Rourke MF: Arterial stiffness as a cause of cognitive decline and dementia: a systematic review and meta-analysis. Internal medicine journal 2012, 42(7):808-815.

Laurent S, Boutouyrie P, Lacolley P: Structural and genetic bases of arterial stiffness. Hypertension 2005, 45(6):1050-1055.

Nichols WW, Nichols WW, McDonald DA: McDonald's blood flow in arteries : theoretic, experimental, and clinical principles, 6th edn. London: Hodder Arnold; 2011.

Redheuil A, Yu WC, Wu CO, Mousseaux E, de Cesare A, Yan R, Kachenoura N, Bluemke D, Lima JA: Reduced ascending aortic strain and distensibility: earliest manifestations of vascular aging in humans. Hypertension 2010, 55(2):319-326.

Vlachopoulos C, Aznaouridis K, Stefanadis C: Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis. Journal of the American College of Cardiology 2010, 55(13):1318-1327.

Kokmen E, Whisnant JP, O'Fallon WM, Chu CP, Beard CM: Dementia after ischemic stroke: a population-based study in Rochester, Minnesota (1960-1984). Neurology 1996, 46(1):154-159.

Peila R, Rodriguez BL, Launer LJ, Honolulu-Asia Aging S: Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: The Honolulu-Asia Aging Study. Diabetes 2002, 51(4):1256-1262.

Launer LJ, Ross GW, Petrovitch H, Masaki K, Foley D, White LR, Havlik RJ: Midlife blood pressure and dementia: the Honolulu-Asia aging study. Neurobiology of aging 2000, 21(1):49-55.

O'Rourke MF, Safar ME: Relationship between aortic stiffening and microvascular disease in brain and kidney: cause and logic of therapy. Hypertension 2005, 46(1):200-204.

Qiu C, Winblad B, Viitanen M, Fratiglioni L: Pulse pressure and risk of Alzheimer disease in persons aged 75 years and older: a community-based, longitudinal study. Stroke; a journal of cerebral circulation 2003, 34(3):594-599.

Fujiwara Y, Chaves PH, Takahashi R, Amano H, Yoshida H, Kumagai S, Fujita K, Wang DG, Shinkai S: Arterial pulse wave velocity as a marker of poor cognitive function in an elderly community-dwelling population. The journals of gerontology Series A, Biological sciences and medical sciences 2005, 60(5):607-612.

Scuteri A, Brancati AM, Gianni W, Assisi A, Volpe M: Arterial stiffness is an independent risk factor for cognitive impairment in the elderly: a pilot study. Journal of hypertension 2005, 23(6):1211-1216.

Benetos A, Watfa G, Hanon O, Salvi P, Fantin F, Toulza O, Manckoundia P, Agnoletti D, Labat C, Gautier S et al: Pulse wave velocity is associated with 1-year cognitive decline in the elderly older than 80 years: the PARTAGE study. Journal of the American Medical Directors Association 2012, 13(3):239-243.

Waldstein SR, Rice SC, Thayer JF, Najjar SS, Scuteri A, Zonderman AB: Pulse pressure and pulse wave velocity are related to cognitive decline in the Baltimore Longitudinal Study of Aging. Hypertension 2008, 51(1):99-104.

Poels MM, van Oijen M, Mattace-Raso FU, Hofman A, Koudstaal PJ, Witteman JC, Breteler MM: Arterial stiffness, cognitive decline, and risk of dementia: the Rotterdam study. Stroke; a journal of cerebral circulation 2007, 38(3):888-892.

Mizushima Y, Oobasawa H, Yoshida S, Irie H, Urata T, Shimoda H: Pulse wave velocity in persons with vascular dementia. Journal of the American Geriatrics Society 2003, 51(9):1329-1330.

Dhoat S, Ali K, Bulpitt CJ, Rajkumar C: Vascular compliance is reduced in vascular dementia and not in Alzheimer's disease. Age and ageing 2008, 37(6):653-659.

Baulmann J, Schillings U, Rickert S, Uen S, Dusing R, Illyes M, Cziraki A, Nickering G, Mengden T: A new oscillometric method for assessment of arterial stiffness: comparison with tonometric and piezo-electronic methods. Journal of hypertension 2008, 26(3):523-528.

Elias MF, Wolf PA, D'Agostino RB, Cobb J, White LR: Untreated blood pressure level is inversely related to cognitive functioning: the Framingham Study. American journal of epidemiology 1993, 138(6):353-364.

van Popele NM, Grobbee DE, Bots ML, Asmar R, Topouchian J, Reneman RS, Hoeks AP, van der Kuip DA, Hofman A, Witteman JC: Association between arterial stiffness and atherosclerosis: the Rotterdam Study. Stroke; a journal of cerebral circulation 2001, 32(2):454-460.

Laurent S, Katsahian S, Fassot C, Tropeano AI, Gautier I, Laloux B, Boutouyrie P: Aortic stiffness is an independent predictor of fatal stroke in essential hypertension. Stroke; a journal of cerebral circulation 2003, 34(5):1203-1206.

Henskens LH, Kroon AA, van Oostenbrugge RJ, Gronenschild EH, Fuss-Lejeune MM, Hofman PA, Lodder J, de Leeuw PW: Increased aortic pulse wave velocity is associated with silent cerebral small-vessel disease in hypertensive patients. Hypertension 2008, 52(6):1120-1126.

Tagawa H, Shimokawa H, Tagawa T, Kuroiwa-Matsumoto M, Hirooka Y, Takeshita A: Long-term treatment with eicosapentaenoic acid augments both nitric oxide-mediated and non-nitric oxide-mediated endothelium-dependent forearm vasodilatation in patients with coronary artery disease. Journal of cardiovascular pharmacology 1999, 33(4):633-640.

Zieman SJ, Melenovsky V, Kass DA: Mechanisms, pathophysiology, and therapy of arterial stiffness. Arteriosclerosis, thrombosis, and vascular biology 2005, 25(5):932-943.

Benetos A, Adamopoulos C, Bureau JM, Temmar M, Labat C, Bean K, Thomas F, Pannier B, Asmar R, Zureik M et al: Determinants of accelerated progression of arterial stiffness in normotensive subjects and in treated hypertensive subjects over a 6-year period. Circulation 2002, 105(10):1202-1207.

Cameron JD, Bulpitt CJ, Pinto ES, Rajkumar C: The aging of elastic and muscular arteries: a comparison of diabetic and nondiabetic subjects. Diabetes care 2003, 26(7):2133-2138.

Safar ME, Czernichow S, Blacher J: Obesity, arterial stiffness, and cardiovascular risk. Journal of the American Society of Nephrology : JASN 2006, 17(4 Suppl 2):S109-111.

Prenner SB, Chirinos JA: Arterial stiffness in diabetes mellitus. Atherosclerosis 2015, 238(2):370-379.

Cecelja M, Chowienczyk P: Dissociation of aortic pulse wave velocity with risk factors for cardiovascular disease other than hypertension: a systematic review. Hypertension 2009, 54(6):1328-1336.

Wang X, Du Y, Fan L, Ye P, Yuan Y, Lu X, Wang F, Zeng Q: Relationships between HDL-C, hs-CRP, with central arterial stiffness in apparently healthy people undergoing a general health examination. PloS one 2013, 8(12):e81778.

Yasmin, McEniery CM, Wallace S, Mackenzie IS, Cockcroft JR, Wilkinson IB: C-reactive protein is associated with arterial stiffness in apparently healthy individuals. Arteriosclerosis, thrombosis, and vascular biology 2004, 24(5):969-974.

Amar J, Ruidavets JB, Bal Dit Sollier C, Bongard V, Boccalon H, Chamontin B, Drouet L, Ferrieres J: Soluble CD14 and aortic stiffness in a population-based study. Journal of hypertension 2003, 21(10):1869-1877.

Vlachopoulos C, Dima I, Aznaouridis K, Vasiliadou C, Ioakeimidis N, Aggeli C, Toutouza M, Stefanadis C: Acute systemic inflammation increases arterial stiffness and decreases wave reflections in healthy individuals. Circulation 2005, 112(14):2193-2200.

Pietri P, Vlachopoulos C, Terentes-Printzios D, Xaplanteris P, Aznaouridis K, Petrocheilou K, Stefanadis C: Beneficial effects of low-dose aspirin on aortic stiffness in hypertensive patients. Vascular medicine 2014, 19(6):452-457.

Feldman M, Jialal I, Devaraj S, Cryer B: Effects of low-dose aspirin on serum C-reactive protein and thromboxane B2 concentrations: a placebo-controlled study using a highly sensitive C-reactive protein assay. Journal of the American College of Cardiology 2001, 37(8):2036-2041.

Ikonomidis I, Andreotti F, Economou E, Stefanadis C, Toutouzas P, Nihoyannopoulos P: Increased proinflammatory cytokines in patients with chronic stable angina and their reduction by aspirin. Circulation 1999, 100(8):793-798.

Henn V, Slupsky JR, Grafe M, Anagnostopoulos I, Forster R, Muller-Berghaus G, Kroczek RA: CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells. Nature 1998, 391(6667):591-594.

Urbina EM, Kimball TR, Khoury PR, Daniels SR, Dolan LM: Increased arterial stiffness is found in adolescents with obesity or obesity-related type 2 diabetes mellitus. Journal of hypertension 2010, 28(8):1692-1698.

Recio-Rodriguez JI, Gomez-Marcos MA, Patino-Alonso MC, Agudo-Conde C, Rodriguez-Sanchez E, Garcia-Ortiz L, Vasorisk g: Abdominal obesity vs general obesity for identifying arterial stiffness, subclinical atherosclerosis and wave reflection in healthy, diabetics and hypertensive. BMC cardiovascular disorders 2012, 12:3.

Pal S, Radavelli-Bagatini S: Association of arterial stiffness with obesity in Australian women: a pilot study. Journal of clinical hypertension 2013, 15(2):118-123.

Wildman RP, Mackey RH, Bostom A, Thompson T, Sutton-Tyrrell K: Measures of obesity are associated with vascular stiffness in young and older adults. Hypertension 2003, 42(4):468-473.

Wildman RP, Farhat GN, Patel AS, Mackey RH, Brockwell S, Thompson T, Sutton-Tyrrell K: Weight change is associated with change in arterial stiffness among healthy young adults. Hypertension 2005, 45(2):187-192.

Mokhtari A, Bellinetto-Ford L, Melander O, Nilsson PM: Determinants of increasing pulse pressure during 23 years' follow-up as a marker of arterial stiffness and vascular ageing. Blood pressure 2008, 17(5-6):291-297.

Budimir D, Jeroncic A, Gunjaca G, Rudan I, Polasek O, Boban M: Sex-specific association of anthropometric measures of body composition with arterial stiffness in a healthy population. Medical science monitor : international medical journal of experimental and clinical research 2012, 18(2):CR65-71.

Desamericq G, Tissot CM, Akakpo S, Tropeano AI, Millasseau S, Macquin-Mavier I: Carotid-femoral pulse wave velocity is not increased in obesity. American journal of hypertension 2015, 28(4):546-551.

Pemberton VL, McCrindle BW, Barkin S, Daniels SR, Barlow SE, Binns HJ, Cohen MS, Economos C, Faith MS, Gidding SS et al: Report of the National Heart, Lung, and Blood Institute's Working Group on obesity and other cardiovascular risk factors in congenital heart disease. Circulation 2010, 121(9):1153-1159.

Yudkin JS, Stehouwer CD, Emeis JJ, Coppack SW: C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue? Arteriosclerosis, thrombosis, and vascular biology 1999, 19(4):972-978.

Park BJ, Lee HR, Shim JY, Lee JH, Jung DH, Lee YJ: Association between resting heart rate and arterial stiffness in Korean adults. Archives of cardiovascular diseases 2010, 103(4):246-252.

Whelton SP, Blankstein R, Al-Mallah MH, Lima JA, Bluemke DA, Hundley WG, Polak JF, Blumenthal RS, Nasir K, Blaha MJ: Association of resting heart rate with carotid and aortic arterial stiffness: multi-ethnic study of atherosclerosis. Hypertension 2013, 62(3):477-484.

Albaladejo P, Asmar R, Safar M, Benetos A: Association between 24-hour ambulatory heart rate and arterial stiffness. Journal of human hypertension 2000, 14(2):137-141.

Cockcroft J: Nebivolol: a review. Expert opinion on pharmacotherapy 2004, 5(4):893-899.

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Published

2015-10-23

How to Cite

Yalcin, A., Atmis, V., Cengiz, O. K., Cinar, E., Varli, M., Aras, S., & Atli, T. (2015). Arterial Stiffness in Older People with Different Types of Dementia Compared to Older People without Cognitive Dysfunction. Asian Journal of Pharmacy, Nursing and Medical Sciences, 3(4). Retrieved from https://ajouronline.com/index.php/AJPNMS/article/view/3078

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