Lipid Profile and Electrolyte Imbalance are Associated with Diabetic Retinopathy in Bangladeshi Population

Authors

  • Md. Golam Kabir Department of Biochemistry and Molecular Biology, University of Chittagong, Chittagong, Bangladesh
  • Deaniel Hossain Department of Biochemistry and Molecular Biology, University of Chittagong, Chittagong, Bangladesh
  • Suman Mohajan Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka, Bangladesh
  • Monsor Rahman Department of Chemistry, Nagarpur Government College, Tangail, Bangladesh

DOI:

https://doi.org/10.24203/ajpnms.v8i3.6206

Keywords:

Keywords—Lipid profile, HbA1c, Electrolytes Diabetic retinopathy, and Diabetes Mellitus.

Abstract

Background: Diabetic retinopathy (DR) is a micro-vascular complication which is the main cause of blindness among people with Diabetes Mellitus. Identification and mitigation of the risk factors associated with DR will help to reduce the visual disability in diabetic subjects.

Aims and objective: The study has been undertaken to explore the association of lipids profile and electrolytes with the diabetic retinopathy in Bangladeshi type 2 diabetic subjects.

Material and methods: In the present study, 63 people diabetic with retinopathy (DR) and 80 people diabetic without retinopathy (DWR) were studied along with 92 healthy controls without family history diabetes and prediabetes. Anthropometric parameters, glucose, triglycerides, total cholesterol, high-density lipoprotein, low-density lipoprotein, glycosylated haemoglobin (HbA1c) and electrolytes Na+, K+, Cl-, HCO3- were measured by standard methods.  

Results: HbA1c of DWR group and DR group were 8.60±1.17 and 11.80±1.63 respectively. Total cholesterol, high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c) were significantly higher (p<0.001) in both DWR and DR group compared to the healthy control. Triglyceride was significantly (p<0.001) higher in the DR group but no difference was found in DWR compared to the control group. K+ was significantly increased in the DR group. Na+, Cl-, HCO3- were significantly decreased in the DR group compared to control group.

Conclusion: These results indicate that diabetic retinopathy patients exhibit dyslipidemia and electrolyte imbalance. Hypertriglyceridemia along with electrolyte imbalance is one the major risk factors toward the progression of diabetic retinopathy.

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Published

2020-06-30

How to Cite

Kabir, M. G., Hossain, D., Mohajan, S., & Rahman, M. (2020). Lipid Profile and Electrolyte Imbalance are Associated with Diabetic Retinopathy in Bangladeshi Population. Asian Journal of Pharmacy, Nursing and Medical Sciences, 8(3). https://doi.org/10.24203/ajpnms.v8i3.6206

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Vol. 8 No. 3 (2020): June 2020

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Copyright (c) 2020 Md. Golam Kabir, Deaniel Hossain, Suman Mohajan, Monsor Rahman

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