Arterial Stiffness in Older People with Different Types of Dementia Compared to Older People without Cognitive Dysfunction
Keywords:
Dementia, arterial Stiffness, pulse wave velocity, older peopleAbstract
Alzheimer’s disease and vascular dementia are the most common causes of cognitive dysfunction among older people. Vascular damage plays a role in the etiopathogenesis of both Alzheimer’s disease and vascular dementia. Arterial stiffness is a marker of vascular damage. The aim of this study was to compare arterial stiffness between Alzheimer’s disease, vascular dementia and controls without memory complaints. A total of 72 older people (Alzheimer’s disease=22, vascular dementia=28, controls=22) were included in the study. Demographic data were obtained and ambulatory blood pressure monitoring was applied. Arterial stiffness was evaluated with carotid to femoral pulse wave velocity measurements. Mean pulse wave velocity was 10.7±2.0 m/s, 11.3±3.1 m/s, and 10.0±3.1 m/s in Alzheimer’s disease, vascular dementia and controls, respectively (p>0.05).Arterial stiffness assessed by pulse wave velocity might play a role in the development of vascular dementia and Alzheimer's disease, but further evidence is needed to confirm this relationship.
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