Association between Serum Vitamin D, Insulin Resistance and Severity of Liver Fibrosis in Chronic Hepatitis C Patients


  • Soheir Said Kamel Professor of Internal Medicine, Faculty of Medicine, Alexandria University
  • Perihan El Sayed Salem Assistant Professor of Internal Medicine, Faculty of Medicine, Alexandria University
  • Ahmed Swidan Assistant Professor of Internal Medicine, Faculty of Medicine, Alexandria University
  • Sara Ibrahim Specialist of Internal Medicine, Fever Hospital, Alexandria University


Vitamin D, Insulin resistance, HOMA-IR, Liver fibrosis, Acoustic Radiation Force Impulse Imaging, Hepatitis C Virus


Liver Fibrosis is a worldwide problem; its diagnosis depends on different modalities as Acoustic Radiation Force Impulse Imaging. Recently, Vitamin D and insulin resistance were linked to liver fibrosis. We aimed to study the association between serum Vitamin D, insulin resistance measured by HOMA-IR and liver fibrosis assessed by Acoustic Radiation Force Impulse Imaging in chronic Hepatitis C patients. The study carried on 60 male patients with chronic Hepatitis C (Group I), and 20 age and sex matched healthy subjects (Group II). All subjects included in this study were subjected to: history taking, routine laboratory investigations, fasting plasma insulin and fasting plasma glucose levels to calculate HOMA-IR, serum Vitamin D level as well as Acoustic Radiation Force Impulse Imaging for assessment of liver fibrosis. HOMA-IR and Acoustic Radiation Force Impulse Imaging readings were significantly high in chronic Hepatitis C patients in comparison to normal controls. On the other hand, serum Vitamin D levels were evidently low among Hepatitis C patients in comparison to normal controls. Acoustic Radiation Force Impulse Imaging, HOMA-IR and serum Vitamin D levels have high ability for the diagnosis of liver fibrosis in Hepatitis C patients.


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How to Cite

Kamel, S. S., Salem, P. E. S., Swidan, A., & Ibrahim, S. (2018). Association between Serum Vitamin D, Insulin Resistance and Severity of Liver Fibrosis in Chronic Hepatitis C Patients. Asian Journal of Applied Sciences, 6(2). Retrieved from