Synthesis of Dihydrocoumarin derivatives from Methyl trans-Cinnamate And Evaluation of their Bioactivity as Potent anticancer Agents

Authors

  • Teni Ernawati Research Center for Chemistry- Indonesian Institute of Sciences (LIPI) Kawasan Puspiptek Serpong, Tangerang Selatan 15314
  • Harpolia Cartika
  • Muhammad Hanafi
  • Ms. Suzana
  • Dila Fairusi

Keywords:

dihydrocoumarin derivatives, methyl trans-cinnmate, cinnamic acid, 4-phenylchroman-2-one, 8-methyl -4- phenylchroman-2-one, and 6-methyl-4-phenylchroman-2-one

Abstract

Synthesis of dihydrocoumarin derivatives from methyl trans-cinnamate is described. The reaction can be carried out as a simple one pot reaction using acid catalyst. Firstly, methyl trans-cinnamate was converted into cinnamic acid via hydrolysis reaction with alkaline. Secondly, esterification reaction of cinnamic acid was carried out by using an acid catalyst p-toluensulfonic acid with phenol, o-cresol, p-cresol which lead to the production of 4-phenylchroman-2-one, 8-methyl -4-phenylchroman-2-one, and 6-methyl-4-phenylchroman-2-one.

 

 

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Published

2014-06-15

How to Cite

Ernawati, T., Cartika, H., Hanafi, M., Suzana, M., & Fairusi, D. (2014). Synthesis of Dihydrocoumarin derivatives from Methyl trans-Cinnamate And Evaluation of their Bioactivity as Potent anticancer Agents. Asian Journal of Applied Sciences, 2(3). Retrieved from https://ajouronline.com/index.php/AJAS/article/view/1297

Issue

Vol. 2 No. 3 (2014): June 2014

Section

Articles

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