Enhancing Dissolution Rates of Gliclazide via Co-crystallization with Nicotinamide


  • Wardiyah S. Prawiro Politeknik Kesehatan Kemenkes Jakarta II
  • Gloria Murtini
  • Tati Suprapti
  • Harpolia Cartika


gliclazide, nicotinamide, co-crystallization, dissolution rate


Gliclazide is a drug with poor water solubility and high permeability (BCS II), The absorption rate of this drug, when taken orally is controlled by dissolution rate in the gastrointestinal tracts. Co-crystallization method is widely used to improve the dissolution rate of this type of drug. This study aims to improve the dissolution rate of gliclazide by Co-crystallization method with nicotinamide as a coformer. Co-crystallization were prepared by solvent evaporation methods using methanol. Pure gliclazide, co-crystal gliclazide-nicotinamide in molar ratio 1:0,5, 1:1, 1:2, 1:2,5, 1:3, 1:3,5, 1:4, 1:5, and 1:7 and physical mixtures were characterized by DSC, FTIR, XRD and dissolution testing. Characterization by DSC and XRD in ratio 1:0,5, 1:1, and 1:2 showed a lower  endothermic peak of gliclazide, and decrease in the intensity of the diffraction pattern by XRD. Characterization by FTIR virtually showed no shift  of absorption peaks of gliclazide in ratio 1:0,5, 1:1, and 1:2. FTIR spectrum of cocrystal in ratio 1:7 showed a shift of absorption peaks for C=O and N-H. Results of dissolution testing for cocrystal in ratio 1:0,5, 1:3, 1:7, and physical mixture in ratio  1:7 showed higher dissolution rate than pure gliclazide. The highest of dissolution rate is cocrystal gliclazide-nicotinamide in ratio 1:7. Similarity analysis (f2) showed no similarity of dissolution rate for pure gliclazide, cocrystal gliclazide-nicotinamide in ratio 1:0,5, 1:3, 1:7 and  physical mixture in ratio  1:7.



Author Biography

Wardiyah S. Prawiro, Politeknik Kesehatan Kemenkes Jakarta II

Department of Pharmacy


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How to Cite

Prawiro, W. S., Murtini, G., Suprapti, T., & Cartika, H. (2016). Enhancing Dissolution Rates of Gliclazide via Co-crystallization with Nicotinamide. Asian Journal of Applied Sciences, 4(4). Retrieved from https://ajouronline.com/index.php/AJAS/article/view/3820