Synthesis of Some New Derivatives of 2-hydrazeno-benzo-thiazole 2-mercpto-benzothiazole and Used as Fungicide Agents
Keywords:
Thiazole, FungicideAbstract
The formation of 2-mercpto -thiol-benzothiazole (C1)was prepared by refluxing the o-amino phenyl mercaptan with carbon disulfide, while the 2- mercpto-benzothiazole was reacted with 37% of formaldehyde to get 2- hydroxyl methyl thiol benzothiazole (C2). Oxime compound (C3) was synthesis through reaction of C1 with chloro acetic acid in presence of sodium hydroxide in ethanol, while the 2-hydrazino-benzonitro-thiazole (C4) was prepared by mixing the C3 with chloroform and para methyl benzoic acid. 1, 2, 4-oxadizole (C5) was prepared by heating the C4 at 100-110 O cand recrystallization from benzene and petroleum ether. The synthesized compounds have been characterized on the basis of IR spectral analysis and the results are compatible with their assigned structures. Derivative compounds syntheses were experienced in vitro for their antifungal activity against Alternaria alternata, Fusarium oxysporium and Verticilliumdahliae, and in the field used the Cucurbita pepo L., as moderate plant. The results indicated that the derivatives compounds were have a good level of inhibitions for fungus species.
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