Rosai-Dorfman's Disease Mimicking Nasopharyngeal Carcinoma: A Preliminary Case Report

Authors

  • Ogah Stephen Agbomhekhe Otolaryngology Division, Department of surgery Federal Medical Centre, Lokoja
  • Olatoke Fatai Federal Medical Centre, Lokoja
  • Awelimobor Daniel Federal Medical Centre, Lokoja
  • Okomanyi Abraham Federal Medical Centre, Lokoja

Keywords:

Rosai-Dorfman, disease, nasopharyngeal, carcinoma

Abstract

We report the case of a 28-year-old female Nigerian with Rosai-Dorfman disease mimicking Nasopharyngeal Carcinoma. Patient presented with bilateral cervical lymphadenopathy of 1 year duration, snoring of 3months duration and difficulty in breathing of 3days duration. Developed progressive worsening difficulty in breathing  and restlessness. No history of weight loss, fever, or epistaxis. On physical examination, patient was in obvious respiratory distress, with signs of upper airway obstruction. Bilaterally enlarged lymph nodes at level 5 and non-tender. Throat examination showed an obvious postnasal mass on tongue depression with a metallic tongue deppressor.  Plain soft tissue neck radiograph revealed narrowed pharyngeal airway caused by a soft tissue mass. Patient was resuscitated and taken to the theatre for emergency tracheostomy, Examination Under Anaesthesia of the postnasal space showed a spherical firm mass which was biopsied. Histology report revealed the mass to be Rosai-Dorfman’s disease. Patient was commenced on low dose prednisolone and the mass is regressing.

 

Author Biographies

Ogah Stephen Agbomhekhe, Otolaryngology Division, Department of surgery Federal Medical Centre, Lokoja

Consultant Otolaryngologist, Head and Neck Surgeon. Otolaryngology Division, Department of Surgery

Olatoke Fatai, Federal Medical Centre, Lokoja

Consultant Otolaryngology, Head and Neck Surgeon, Federal Medical Centre, Lokoja

Awelimobor Daniel, Federal Medical Centre, Lokoja

Consultant Pathologist, Federal Medical Centre, Lokoja

Okomanyi Abraham, Federal Medical Centre, Lokoja

Medical Officer, Federal Medical Centre, Lokoja

References

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. Levine PH, Jahan N, Murari P, et al. Detection of Human Herpesvirus 6 in Tissues Involved by Sinus Histiocytosis with Massive Lymphadenopath y (Rosai-Dorfman Disease). J Infect Dis 1992; 166: 291-295

. Pulsoni A, Anghel G, Falcucci P, et al. Treatment of sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): report of a case and literature review. Am J Hematol 2002; 69: 67-71

. Hadjipanayis CG, Bejjani G, Wiley C, et al. Intracranial Rosai-Dorfman disease treated with microsurgical resection and stereotactic radiosurgery. Case report. J Neurosurg 2003; 98: 165-168

. Scheel MM, Rady PL, Tyring SK, et al. Sinus histiocytosis with massive lymphadenopathy: presentation as giant granuloma annulare and detection of human herpesvirus 6. J Am Acad Dermatol 1997; 37: 643-646

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Published

2014-08-15

How to Cite

Agbomhekhe, O. S., Fatai, O., Daniel, A., & Abraham, O. (2014). Rosai-Dorfman’s Disease Mimicking Nasopharyngeal Carcinoma: A Preliminary Case Report. Asian Journal of Pharmacy, Nursing and Medical Sciences, 2(4). Retrieved from https://ajouronline.com/index.php/AJPNMS/article/view/1537

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