Pregnancy Chances in Women over the Age of Forty
Keywords:Ovarian Reserve, Dehydroepiandrosterone (DHEA) supplementation, ovarian stimulation
Objective:To determine whether Dehydroepiandrosterone (DHEA)Â improve ovarian response and pregnancy potential in women Â whose age is â‰¥ 40 years, and whether such potential is age dependent.
Methods: Between January 2013 and October 2013, 39 infertile women â‰¥ 40 years were prospectively evaluated for ovarian response and pregnancy chances without and with DHEA treatment (A= 22 normal ovarian reserve & B= 17 poor ovarian reserve).
Results: Â Group B women have Â a significant lower baseline Anti Mullerian Hormone and Estradiol indicating a poor ovarian reserve. There were insignificant difference between the two Â groups in term of follicle numbers after controlled ovarian stimulation, and the pregnancy rate is significantly better in group A.
Conclusion: our study failed to demonstrate any beneficial effect of DHEA to improve OR in women above or = 40 with baseline poor OR in term of Â follicular recruitment and pregnancy rate after controlled ovarian stimulation. Efficacy of androgen supplementation with DHEA seems to vary depending on female age and baseline OR.
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