Pregnancy Chances in Women over the Age of Forty
Keywords:
Ovarian Reserve, Dehydroepiandrosterone (DHEA) supplementation, ovarian stimulationAbstract
Objective:To determine whether Dehydroepiandrosterone (DHEA) improve ovarian response and pregnancy potential in women  whose age is ≥ 40 years, and whether such potential is age dependent.
Methods: Between January 2013 and October 2013, 39 infertile women ≥ 40 years were prospectively evaluated for ovarian response and pregnancy chances without and with DHEA treatment (A= 22 normal ovarian reserve & B= 17 poor ovarian reserve).
Results:  Group B women have  a significant lower baseline Anti Mullerian Hormone and Estradiol indicating a poor ovarian reserve. There were insignificant difference between the two  groups in term of follicle numbers after controlled ovarian stimulation, and the pregnancy rate is significantly better in group A.
Conclusion: our study failed to demonstrate any beneficial effect of DHEA to improve OR in women above or = 40 with baseline poor OR in term of  follicular recruitment and pregnancy rate after controlled ovarian stimulation. Efficacy of androgen supplementation with DHEA seems to vary depending on female age and baseline OR.
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