The Role of Ovarian Reserve Tests in predicting Intra-Cytoplasmic Sperm Injection Cycles Outcome
Keywords:Ovarian reserve, ovarian reserve markers, Antimullerian hormone, Intracytoplasmic sperm injection outcomes
Aims: 1. to assess the ovarian reserve (OR) for subpopulations of Iraqi infertile couples seeking Intra Cytoplasmic Sperm Injection (ICSI) treatment. 2. To correlate the OR markers with ICSI outcome. Study design:Â a prospective randomized controlled trial. Patients and methods: Eighty -seven participants were enrolled during their attendance to fertility center of Al-Sadar Medical Teaching city in Al- Najaf Province; twenty subjects as a control group (n=20), and 67 as a study group (n=67). Ovarian reserve parameters were assessed and ICSI were performed. Â We correlate the OR markers with: No. of follicles obtained, No. of mature oocytes, Fertilization rate, Cleavage rate, Embryo scoring, No. of embryo transferred and Pregnancy rate (biochemical pregnancy).Â Â Results: AgeÂ resultedÂ in significant negative correlation with No. of follicles, No. of mature oocytes at metaphase II (MII), No. of two pronuclear phase (2PN),No. of best quality embryos grade one and two (G1+G2),and to the total No. of embryos transferred ;while basalÂ serum level of anti mullerian hormone (AMH) follows ageÂ as itÂ shows positive significant correlation withÂ The No. of MII oocytes obtainedÂ ,Â No. of best quality embryos ,itÂ correlate positively and significantly to the level of serumÂ AMH. Basal serum level of Follicle stimulating hormone (FSH) shows significant negative correlation with No. of follicles aspirated and to No. of MII oocytes. Basal serum levels of estradiol and inhibin B didnâ€™t show significant correlation with ICSI outcomes. None of the OR markers correlates with pregnancy rate.Conclusion: Â Age, Anti-Mullerian hormone and follicle stimulating hormone are better markers than inhibin B, estradiol or antral follicle count in predicting the outcome of ICSI cycles.
Wallace WHB & Kelsey TW. Human ovarian reserve from conception to menopause. Polson; 5 (1): 87772; 2010
Tietze C. Reproductive spans and rate of reproduction among Htterite women. Fertil Steril.;8: 89-97. 1957
American Society of Reproductive Medicine (ASRM). Age related fertility decline: a committee opinion; 90-s: 154- 5; 2008.
Baird DT, Collins J, Egozcue J et al. Fertility and aging. Hum Reprod update. 11: 261-76; 2005
Weinstein M, Wood AJ & Chang MC .Age pattern in fecundability. Gray R, Leridon H, Spira A, (eds).In: Biomedical and Demographic determination s of Reproduction. Clarendon Press. Oxford. 209-220; 1993
Jackson MM .Using Anti-mullerian hormone to measure ovarian reserve. Clinical update; 1: 2010 http://www.Walgreen shealty.com.
Roseboom TJ, Vermeiden JP, Schoute E et al. The probability of pregnancy after embryo transfer is affected by the age of the patient, cause of infertility,numberof embryo transferred and the average morphology score ,as revealed by multilogistic regression analysis . Hum Reprod.. 10:3055-3041; 1995.
Chang CC, Chen CD, Chao KH et al. Age is a better predictor of pregnancy potential than basal level in women undergoing IVF. IVF. 79: 63â€”68; 2003
Terriou P, Sapin C, Giorgetti A et al. Embryo score is a better predictor of pregnancy than the number of transferred embryos or female age. Fertil Steril. 75:525-531; 2001.
Miller JH, Weinborg RK, Canino NL et al. The pattern of infertility diagnosis in women of advanced reproductive age. Am J Obestet Gynecol. 181:952-957;1999.
Maheshwari A, Hamilton M, Bhattacharya S. Effect of female age on the diagnostic categories of infertility. Hum Reprod; 23:538-542; 2008
Cooper TG, Noonan E, von Eckardstein S, Auger J, G Baker HW, Behre H M, et al. World Health Organization reference values for human semen characteristics. Hum Reprod Update; 16(3): 231â€“245; 2010.
The Rotterdam ESHRE/ASRM-Sponsored PCOSConsensus Workshop Group 2004 Revised 2003 consens us on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS).Hum Reprod .19:41â€“47
Steer CV, Mills CL, Tans L, Capbell S & Edward RG.The cumulative embryo scoring : a predictive embryo scoring technique to select the optimal numbers of embryo to transfer in an IVF and ET programs. Hum Reprod.; 7: 117- 119;1992.
BÄ…czkowski T, Kurzawa R & Glabowski W . Method of embryo scoring in In Vitro Fertilisation. Reprod Biology. 4(1): 5-22; 2004.
Scott RT Jr & Hofmann GE Prognostic assessment of ovarian reserve. Fertil Steril.63:1â€“11; 1995.
Bukman A & Heinemann MJ. Ovarian reserve testing and the use of prognostic models in patients with subfertility. Hum Reprod Update; 7:581â€“590; 2001.
Sharara FI, Scott RT & Seifer BB. The detection of diminished ovarian reserve in infertile women. Am J Obstet Gynecol.; 179:804â€“12 ;1998.
Durlinger AL, Kramer P, Karels B, de Jong FH, Uilenbroek JT, Grootegoed JA, et al. Control of primordial follicle recruitment by anti-Mullerian hormone in the mouse ovary. Endorinology.; 12:5789-5796; 1999.
La Marca A & Volpe A .Anti-MÃ¼llerian hormone (AMH) in female reproduction: is measurement of circulating AMH a useful tool? Clin Endocrinol (Oxf); 64: 603-610; 2006
FicÂ¸icioË‡glu C, Kutlu K, Baglam E & Bakacak Z. Early follicular antimÂ¨ullerian hormone as an indicator of ovarian reserve. Fertil Steril.; 85(3): 592â€“596; 2006.
.Visser JA, De Jong FH, Laven JS & Themmen AP. Anti-MÃ¼llerian hormone: a new marker for ovarian function. Reproduction; 131: 1-9; 2006.
Hehenkamp WJ, Looman CW, Themmen AP, de Jong FM, Te Velde ER, Broekmans FJ . Anti-MÃ¼llerian hormone levels in the spontaneous menstrual cycle do not show substantial fluctuation. J Clin Endocrinol Metab.; 91:4057â€“4063;2006.
van Disseldorp J, Lambalk CB, Kwee J, Looman CW, Eijkemans MJ, Fauser BC, Broekmans FJ. Comparison of inter- and intra-cycle variability of anti-Mullerian hormone and antral follicle counts. Hum Reprod;25(1):221-7;2010.
Sharif K, Elgendy M, Lashen H & Afnan M .Age and basal follicle stimulating hormone as predictors of in vitro fertilisation outcome. Br J Obstet Gynaecol. 105:107-112; 1998
Spandorfer SD, Avrech OM, Colombero LT, Palermo GD & Rosenwaks Z: Effect of parental age on fertilization and pregnancy characteristics in couples treated by intracytoplasmic sperm injection. Hum Reprod. 13:334â€“8; 1998.
Karimzadeh MA, Ghandi S & Tabibnejad N : Age as a predictor of Assisted Reproductive Techniques outcome. Pak J Med Sci. 24:378-381; 2008.
Karimzadeh MA & Ghandi S: Age and basal FSH as a predictor of ART outcome. Iranian Journal of Reproductive Medicine. (7): 19-22; 2009.
Frattarelli JL, Bergh PA, Drews MR, Sharara F I & Scott Jr RT: Evaluation of basal estradiol levels in assisted reproductive technology cycles. Fertil Steril. 74(3):518â€“524; 2000.
de Carvalho BR, Rosa ACJ, Silva E, Rosa JC, Silva E, Dos Reis RM et al.: Use of ovarian reserve markers and variables of response to gonadotropic stimulus as predictors of embryo implantation in ICSI cycles,â€ Jornal Brasileiro de Reproducao Assistida.13:26â€“29; 2009.
Creus M, PeÃ±arrubia J, FÃ¡bregues F, Vidal E, Carmona F, Casamitja et al.: Day 3 serum inhibin B and FSH and age as predictors of assisted reproduction treatment outcome. Hum Reprod. 15:2341-2346; 2000.
Lin WQ, Yang HY, Lin JJ, Chen X & Ye BL : Correlation between serum inhibin B level after treatment with gonadotropin releasing hormone agonist and outcome of in vitro fertilization-embryo transfer. Zhonghua Fu Chan Ke Za Zhi. 44(4):260-2; 2009.
Hall JE, Welt CK & Cramer DW: Inhibin A and inhibin B reflect ovarian function in assisted reproduction but are less useful at predicting outcome. Hum Reprod.14 (2):409â€“415;1999.
Irez T, Ocal P, Guralp O, Cetin M, Aydogan B & Sahmay S: Different serum anti-MÃ¼llerian hormone concentrations are associated with oocyte quality, embryo development parameters and IVF-ICSI outcomes,â€ Archives of Gynecology and Obstetrics. 284: 1295â€“1301; 2011.
Hazout A, Bouchard P, Seifer DB, Aussage P, Junca AM & Cohen-Bacrie P: Serum antimullerian hormone/mullerian-inhibiting substance appears to be a more discriminatory marker of assisted reproductive technology outcome than follicle-stimulating hormone, inhibin B, or estradiol. Fertil Steril. 82:1323-1329; 2004
Arabzadeh S, Hossein G, Rashidi BH, Hosseini MA & Zeraati H: Comparing serum basal and follicular fluid levels of anti-MÂ¨ullerian hormone as a predictor of in vitro fertilization outcomes in patients with and without polycystic ovary syndrome. Annals of Saudi Medicine. 30(6):442â€“509; 2010.
Melo MA, Garrido N, Alvarez C, Bellver J, Meseguer M, Pellicer A et al.: Antral follicular count can be used in the prediction of ovarian response but canâ€™t predict the oocyte / embryo quality or the in vitro fertilization out come in an egg donation program. Fertil Steril. 91:148-56; 2009.
Majumder K, Gelbaya TA, Laing I & Nardo LG: The use of anti-MÃ¼llerian hormone and antral follicle count to predict the potential of oocytes and embryos. Eur J Obstet Gynecol Reprod Biol. 150(2):166-70;2010.
Greb RR, Grieshaber K, Gromoll J, Sonntag B, Nieschlag E, Kiesel L et al.: A common single nucleotide polymorphism in exon 10 of the human follicle stimulating hormone receptor is a major determinant of length and hormonal dynamics of the menstrual cycle. J Clin Endocrinol Metab. 90:4866-4872; 2005.
Brodin T. Ovarian Reserve and Assisted Reproduction. ACTA UNIVERSITATIS UPSALIENSIS UPPSALA; 2013. Ph.D thesis. ISSN 1651-6206; ISBN 978-91-554-8592-4; urn: nbn: see: uu: diva-192998.
Faddy MJ, Gosden RG, Gougeon A, Richardson SJ & Nelson JF: Accelerated disappearance of ovarian follicles in mid-life: implications for forecasting menopause. Hum Reprod. 7:1342â€“1346.Hum Reprodn Update (12) 6: 685â€“718; 1992.
Toner JP, Philput CB, Jones GS & Muasher SJ: Basal follicle-stimulating hormone level is a better predictor of in vitro fertilization performance than age. Fertil Steril. 55: 784-791; 1991.
Jones KT: Meiosis in oocytes: predisposition to aneuploidy and its increased incidence with age. Hum Reprod Update. 14:143â€“158; 2008.
Ottolenghi C, Uda M, Hamatani T, Crisponi L, Garcia JE, Ko M et al.: Aging of oocyte, ovary, and human reproduction. Ann NY Acad Sci. 1034:117â€“131; 2004.
Broekmans FJ, Kwee J, Hendriks DJ , Lambalk CB et al.: â€œA systematic review of tests predicting ovarian reserve and IVF outcome,â€ Hum Reprodn Update(12) 6: 685â€“718. 2006.
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