Disinfecting Effects of Decontamination Solutions and Ultraviolet Irradiation on Exposure to Cyclophosphamide or 5-Fluorouracil Inside Biological Safety Cabinets
DOI:
https://doi.org/10.24203/ncxxjr23Keywords:
antineoplastic drugs, cyclophosphamide, decontamination, UV irradiation, 5-fluorouracilAbstract
To ensure safe decontamination in Biological Safety Cabinets (BSCs), we evaluated various solutions and ultraviolet (UV) irradiation against anticancer drugs. Cyclophosphamide (CPA) and 5-fluorouracil (5-FU) were tested. After 16 h of UV exposure, CPA degraded to 42–55% of its initial amount, while 5-FU showed minimal reduction. A single wipe with purified water effectively decreased drug residues, and the combination of purified water and UV irradiation was most effective for CPA. In contrast, a 0.1% benzalkonium chloride solution showed poor performance with or without UV. Overall, physical cleaning with purified water followed by UV irradiation offers a practical and reliable decontamination method in routine hospital practice.
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