Correlation of Fischer’s Ratio with Liver Fibrosis in Naive Chronic Hepatitis B Patients without Comorbidities


  • Mohammad Rilwanu Rafsanjani Resident of Internal Medicine, Sebelas Maret University, Surakarta, Indonesia
  • Triyanta Yuli Pramana Departement of Internal Medicine, Gastro Entero, Hepatology Subdivision, Sebelas Maret University, urakarta, Indonesia
  • Arifin Departement of Internal Medicine, Infection Subdivision, Sebelas Maret University, Surakarta, Indonesia



Hepatitis B, Fisher's ratio, Liver Fibrosis, hepatitis



Hepatitis B virus infection is one of the most common health problems in the world. 20% Chronic hepatitis B can can change into liver fibrosis. The liver is the center of the body's Amino Acids metabolism. Amino acid changes can occur due to impaired liver function. Fisher's ratio (BCAA/AAA) has become one of the sign of liver fibrosis. This study wanted to find a relationship between Fischer Ratio values and liver fibrosis in naive chronic hepatitis B patients without comorbidities.


The research was conducted from October 2020-May 2021 at DR. Moewardi Hospital, Surakarta, Indonesia. Subjects were naive chronic hepatitis B patients without comorbidities with a minimum age of 30 years. The study used a cross-sectional method. Fischer Ratio values were assessed by spectrophotometry and liver fibrosis was assessed by transient elastography (fibroscan). A correlation test was conducted to determine the relationship between variables.


20 patients were included in the study. The average age of the research subjects was 47 ± 10 years. The average Fisher's ratio value was 2.83 ± 1.16 and the average fibroscan value was 17.31 ± 18.50 kPa. Ratio Fischer had a correlation with liver fibrosis with r= - 0.571 (p=0.004).


Ratio Fischer has a negative correlation with liver fibrosis in naive chronic hepatitis B patients without comorbidities.




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How to Cite

Rafsanjani, M. R., Pramana, T. Y. ., & Arifin. (2021). Correlation of Fischer’s Ratio with Liver Fibrosis in Naive Chronic Hepatitis B Patients without Comorbidities. Asian Journal of Pharmacy, Nursing and Medical Sciences, 9(6).