False Covid-19 Test Results – Could We Do Things Better? A Personal Opinion

Authors

  • Suzanne Lisbeth Ekelund Retired Principal Specialist, Clinical Biochemist, M. Sci. Roedovre, Denmark

DOI:

https://doi.org/10.24203/ajpnms.v8i5.6349

Keywords:

covid-19, test strategy, positive predictive value, false positive results, false negative results

Abstract

This paper describes the problems with false covid-19 test results, both false positive and false negative results. The problems are related to the quality of tests, test sampling and the currently limited follow-up procedures. A test and follow-up strategy that could decrease the potential problems is suggested.

References

Sundhedsstyrelsen: Information om PCR test for COVID-19 til almen praksis. April 14,2020 (https://www.sst.dk/-/media/Udgivelser/2020/Corona/IRF-Almen-praksis/Kommunikation-til-almen-praksis_test-af-COVID.ashx?la=da&hash=A28AC860410928AAD8864F689B6A05C9E56F3A87)

Keller J, Liyanage SE, Hingorani M, Hingorani A. Probability of encountering Covid-19 patients based on prevalence and testing during resumption of ophthalmology services. Eye (Lond) 2020;16:1-2. doi: 10.1038/s41433-020-1089-4. Online ahead of print. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7364291/)

Sundhedsstyrelsen. Tal og overvågning: COVID-19 (https://www.sst.dk/da/corona/tal-og-overvaagning)

Wernike K, Keller M, Conraths FJ, Mettenleiter TC, Groschup MH, Beer M. Pitfalls in SARS-CoV-2 PCR diagnostics.

Transbound Emerg Dis 2020;14:10.1111/tbed.13684. doi: 10.1111/tbed.13684. Online ahead of print. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323359/)

Basso C, Leone O, Rizzo S, De Gaspari M, van der Wal AC, Aubry MC, Bois MC, Lin PT, Maleszewski JJ, Stone JR. Pathological features of COVID-19-associated myocardial injury: a multicentre cardiovascular pathology study.Eur Heart J 2020 Sep 24:ehaa664. doi: 10.1093/eurheartj/ehaa664. Online ahead of print.

Wichmann D, Sperhake JP, Lütgehetmann M, Steurer S, Edler C, Heinemann A, Heinrich F, Mushumba H, Kniep I, Schröder AS, Burdelski C, de Heer G, Nierhaus A, Frings D, Pfefferle S, Becker H, Bredereke-Wiedling H, de Weerth A, Paschen HR, Sheikhzadeh-Eggers S, Stang A, Schmiedel S, Bokemeyer C, Addo MM, Aepfelbacher M, Püschel K, Kluge S. Autopsy Findings and Venous Thromboembolism in Patients With COVID-19: A Prospective Cohort Study.

Ann Intern Med 2020 Aug 18;173(4):268-277. doi: 10.7326/M20-2003. Epub 2020 May 6.

Jacofsky D, Jacofski EM, Jacofski M. Understanding Antibody Testing for COVID-19. J Arthroplasty 2020; 35(7): S74-S81. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184973/)

Liu A, Wang W, Zhao X, Yang D, Lu M, Lv Y. Disappearance of antibodies to SARS-CoV-2 in a -COVID-19 patient after recovery. Clin Microbiol Infect 2020; Epub ahead of print. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346807/)

Downloads

Published

2020-10-31

How to Cite

Ekelund, S. L. (2020). False Covid-19 Test Results – Could We Do Things Better? A Personal Opinion. Asian Journal of Pharmacy, Nursing and Medical Sciences, 8(5). https://doi.org/10.24203/ajpnms.v8i5.6349