Protocol Development for Preventing Contrast-Induced Nephropathy


  • Rana Ibrahim University of Sharjah
  • Osama Mohamed Ibrahim University of Sharjah



Nephropathy, hydration, radiographic contrast, dialysis, renal perfusion


Contrast-induced nephropathy (CIN) is related to substantial economic and clinical consequences, including extended hospitalization, the necessity for dialysis, and an amplified risk of death. As radiographic diagnostic testing becomes commonplace, a significant concern among practitioners is the prevention of radiographic contrast-induced nephropathy. Radiographic contrast agents are used most often in tests such as coronary angiography, percutaneous coronary angioplasty, atherectomy, and stent placement, computer-aided tomography (CAT) scanning, and magnetic resonance imaging (MRI). 1 Administration of these contrast agents often cause acute changes in renal function ranging from an acute reduction of renal function to the transient need for hemodialysis.


Early studies assessing the renal effects of radiocontrast administration in dogs proved a reduction in renal perfusion lasting up to 20 hours after radiocontrast administration. 8 Although no randomized controlled trial (RCT) has studied the benefits of hydration alone, it appears reasonable that sufficient hydration may offset some of the presumed hemodynamic effects that could lead to contrast-induced nephropathy. Various preventative strategies have been studied with mixed results.


This paper constitutes reviewing current and old practices and developing a tentative simple protocol for prevention of Contrast induced nephropathy in nearby hospitals.

Author Biographies

Rana Ibrahim, University of Sharjah

Department of Pharmacy Practice and Pharmacotherapeutcis

Lecturer in Pharmacy Practice and Clinical Pharmacy

Osama Mohamed Ibrahim, University of Sharjah

Associate Professor of Clinical Pharmacy and Pharmacy practice

Department of Pharmacy Practice and Pharmacotherapeutics


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How to Cite

Ibrahim, R., & Ibrahim, O. M. (2018). Protocol Development for Preventing Contrast-Induced Nephropathy. Asian Journal of Pharmacy, Nursing and Medical Sciences, 6(3).