ABO Genotype and Risk of Recurrent Pregnancy Loss in Carriers of FVL in Palestinian Population
Keywords:
Recurrent pregnancy loss, factor V Leiden, ABO genotypesAbstract
The aim of this study was to define ABO genotypes in the Palestinian population and to assess the impact of ABO blood group genotypes and FV Leiden and we investigated whether predisposition to RPL was higher in non-OO genotype carriers than in OO genotype carriers. The study included 209 subjects suffered from RPL : 85 FV Leiden carriers as case group and 124 as a control group. Genotyping to 5 common alleles of ABO blood groups was performed by allele specific polymerase chain reaction with specific primers (AS-PCR). The results showed that there was no association between non-OO blood group genotypes and the risk of RPL(odds ratio [OR] 1.4, 95% confidence interval [95% CI] 0.74-2.6). Comparison of OO genotype and non-OO genotype carriers between case and control subjects yielded a higher OR in A1A1 / A1A2 blood group genotypes (OR: 2.2, 95% CI: 0.6- 8.19), followed by A1O1 / A1O2 (OR:1.6,95% CI: 0.77-3.55) B1B1/ B1O1/ B1O2 (OR: 1.3, 95% CI: 0.6-2.76) and A1B/ A2B (OR: 1.2, 95% CI: 0.33-4.00) which did not reach statistical significance. The results of ABO genotyping showed no statistically significant difference in the frequency of OO and non-OO genotype carriers between the case group who had FVL and the control group (OR: 1.4, 95% CI : 0.74-2.6).
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