Polyamines: An Essentially Regulatory Modulator of Plants to Abiotic Stress Tolerance: A Review


  • Fahmida Aktar Department of Biotechnology and Genetic Engineering, Faculty of Biological Sciences, Islamic University, Kushtia-7003, Bangladesh
  • Md. Shahidul Islam Department of Biotechnology and Genetic Engineering, Faculty of Biological Sciences, Islamic University, Kushtia-7003, Bangladesh
  • Md. Al-Amin Milon Department of Biotechnology and Genetic Engineering, Faculty of Biological Sciences, Islamic University, Kushtia-7003, Bangladesh
  • Nahidul Islam Department of Biotechnology and Genetic Engineering, Faculty of Biological Sciences, Islamic University, Kushtia-7003, Bangladesh
  • Md Azizul Islam Department of Biotechnology and Genetic Engineering, Faculty of Biological Sciences, Islamic University, Kushtia-7003, Bangladesh




Abiotic stress, polyamines, stress tolerance, ROS, Transgenic plants


Environmental stimuli including abiotic stresses, most notably salinity, drought, and cold stress greatly impact the growth, development, productivity, and disposal of plants worldwide. It has been calculated that two-thirds of the sustainable crop productivity are routinely facing a great challenge due to the unfavorable environmental factors by reducing the potential yield. There is a substantial amount of evidence to support that polyamines (PAs) are highly accumulated under abiotic stresses. PAs have a low molecular weight, are positively charged at physiological pH, and have a high affinity for nucleic acids and membrane phospholipids, which are found in all living cells. The most frequently used putrescine (Put), spermidine (Spm), and spermine (Spm) are well-known PAs that play a significant role in cell growth and development, leaf senescence, embryogenesis, and modulating plant tolerance to a wide range of abiotic stresses. These studies are highlights to dissever the action of polyamines mechanism in order to develop new strategies to enhance plant continuity in unfavorable environmental conditions.


Author Biography

Md Azizul Islam, Department of Biotechnology and Genetic Engineering, Faculty of Biological Sciences, Islamic University, Kushtia-7003, Bangladesh

Dept of Biotechnology and Genetic Engineering, Islamic University-Kushtia, Bangladesh.


Tuteja N. and Sopory S.K., “Chemical signaling under abiotic stress environment in plants”, Plant Signal Beh, vol. 3, pp.525-36, 2008.

Mahajan S. and Tuteja N., “Cold, salinity and drought stresses: An overview”, Arch Biochem Biophy, vol. 444, pp.139-58, 2005.

Sanghera G.S., Wani S.H., Hussain W., and Singh N.B., “Engineering cold stress tolerance in crop plants”, Curr Genomics, vol. 12, pp.30-43, 2011.

Wang W., Vinocur B., and Altman A., “Plant responses to drought, salinity and extreme temperature: towards genetic engineering for stress tolerance”, Planta, vol. 218, pp.1-14, 2003.

Zhao H. and Yang H., “Exogenous polyamines alleviate the lipid peroxidation induced by cadmium chloride stress in Malus hupehensis Rehd”, Sci Hortic, vol. 116, pp.442-7, 2008.

Martin-Tanguy J., “Metabolism and function of polyamines in plants: recent development (new approaches)”, Plant Growth Regul, vol. 34, pp.135-148, 2001.

Liu J-H., Kitashiba H., Wang J., Ban Y., and Moriguchi T., “Polyamines and their ability to provide environmental stress tolerance to plants”, Plant Biotechnol, vol. 24, pp.117-26, 2007.

Kasukabe Y., He L., Nada K., Misawa S., Ihara I., and Tachibana S., “Overexpression of spermidine synthase enhances tolerance to multiple environmental stresses & up-regulates the expression of various stress regulated gene in transgenic Arabidopsis thaliana”, Plant Cell Physiol, vol. 45, pp.712-722, 2004.

Alet A.I., Sanchez D.H., Cuevas J.C., Valle S.D., Altabella T., Tiburcio A.F., Marco F., Ferrando A., Espasandin F.D., González M.E., Ruiz O.A., and Carrasco P., “ Putrescine accumulation in Arabidopsis thaliana transgenic lines enhances tolerance to dehydration & freezing stress”, Plant Signal Behav, vol. 6, pp.278-286, 2011.

Roy M. and Wu R., “Overexpression of S-adenosylmethionine decarboxylase gene in rice increases polyamine level & enhances sodium chloride stress tolerance”, Plant Sci, vol. 163, pp.987-92, 2002.

Sarvajeet S.G. and Narendra T., “Polyamines & abiotic stress tolerance in plants”, Plant Signaling & Behavior, vol. 5, pp.126-33, 2010.

Perez-Amador M.A., Leon J., Green P.J., and Carbonell J., “Induction of the Arginine decarboxylase ADC2 gene provides evidence for the involvement of polyamines in the wound response in Arabidopsis”, Plant Physiol, vol. 130, pp.1454-63, 2002.

Hanfrey C., Sommer S., Mayer M.J., Burtin D., and Michael A.J., “Arabidopsis polyamine biosynthesis: absence of ornithine decarboxylase and the mechanism of arginine decarboxylase activity”, Plant Journal, vol. 27, pp.551-560, 2001.

Liu Ji-H., Nada K., Honda C., Kitashiba H., Wen X.P., Pang X.M., and Moriguchi T., “Polyamine biosynthesis of apple callus under salt stress: importance of Arginine decarboxylase pathway in stress response”, J Exp Bot, vol. 57, pp.2589-99, 2006.

Hummel I., Gouesbet G., El Amrani A., Ainouche A., and Couee I., “Characterization of the two arginine decarboxylase (polyamine biosynthesis) paralogues of the endemic subantarctic cruciferous species Pringlea antiscorbutica & analysis of their differential expression during development and response to environment at stress”, Gene, vol. 342, pp.199-209, 2004.

Alcázar R., Marco F., Cuevas J.C., Patron M., Ferrando A., Carrasco P., Tiburcio A.F., and Altabella T., “Involvement of polyamines in plant response to abiotic stress”, Biotechnol Lett, 2006; vol. 28, pp.1867-1876, 2006.

Mukherjee K., Choudhury A.R., Gupta B., Gupta S., and Sengupta D.N., “An ABRE-binding factor, OSBZ8, is highly expressed in salt tolerant cultivars than in salt sensitive cultivars of indica rice”, BMC Plant Biol, vol. 6, pp.18, 2006.

Bagni N. and Tassoni A., “Biosynthesis, oxidation & conjugation of aliphatic polyamines in higher plants”, Amino Acids, vol. 20, pp.301-317, 2001.

Yoda H., Hamaguchi R., and Sano H., “Induction of hypersensitive cell death by hydrogen peroxide produced through polyamine degradation in tobacco plants”, Plant Physiol, vol. 132, pp.1973-1981, 2003.

Rodriguez A.A., Maiale S.J., Menendez A.B., and Ruiz O.A., “Polyamine oxidase activity contributes to sustain maize leaf elongation under saline stress”, J Exp Bot, vol. 60, pp.4249-4262, 2009.

Miller G., Shulavev V., and Miller R., “ Reactive oxygen signaling & abiotic stress”, Plant Physiol, vol. 133, pp.481-489, 2008.

Islam M.A., Maitra P., Biswas S.K., and Faruquee H.M., “Actions of polyamine on abiotic stresses in rice”, IJSER, vol. 9, pp.73-80, 2018.

Mansour M.M.F., and Al-Mutawa M.M., “Stabilization of plasma membrane by polyamines against salt stress”, Cytobios, vol. 100, pp.7-17, 1999.

El-Shintinawy F., “Photosynthesis in two wheat cultivars differing in salt susceptibility”, Photosynthetica, vol. 38, pp.615-620, 2000.

Imai R., Ali A., Pramanik M.H.R., Nakaninami K., Sentoku N., and Kato H., “A distinctive class of spermidine synthase is involved in chilling response in rice”, J Plant Physiol , vol. 161, pp.883-886, 2004.

Fait A., Fromm H., Walter D., Galili G., and Fernie A.R., “Highway or byway; the metabolic role of the GABA shunt in plants”, Trends Plant Sci, vol. 13, pp.14-19, 2008.

Hsu S.Y., Hsu Y.T., and Kao C.H., “The effect of polyethylene glycol on proline accumulation in rice leaves”, Biol Plant ,vol. 46, pp.73-78, 2003.

DO P.T., Degenkolbe T., Erban A., Heyer G.A., Kopka J., Kohl K.I., Hincha D.K., and Zuther E., “Dissecting rice polyamine metabolism under controlled long-term drought stress”, PLOS ONE, vol. 8, pp.e60325, 2013.

Yang J., Zhang J., Liu K., Wang Z., and Liu L., “Involvement of polyamines in the drought resistance of rice”, J Exp Botany, vol. 58, pp.1545-1555, 2007.

Capell T., Bassie L., and Christou P., “Modulation of the polyamine biosynthetic pathway in transgenic rice confers tolerance to drought stress”, Proc Natl Acad Sci USA, vol. 101, pp.9909-9914, 2004.

Peremarti A., Bassie L., Christou P., and Capell T., “Spermine facilitates recovery from drought but does not confer drought tolerance in transgenic rice plants expressing Datura stramonium S-adenosylmethionine decarboxylase”, Plant Mol Biol, vol. 70, pp.253-264, 2009.

Boucherau A., Aziz A., Larher F., and Martin-TanguyJ., “Polyamines & environmental challenges; recent development”, Plant Sci, vol.140, pp.103-125, 1999.

Galston A.W., Kaur-Sawhney R., Altabella T., and Tiburcio A.F., “Plant polyamines in reproductive activity and response to abiotic stress”, Bot Acta, vol. 110, pp.197-207, 1997.

Cona A., Rea G., Angelini F., Federcio R., and Tavladoraki P., “Functions of amine oxidase in plant development & defence”, Trends Plant Sci ,vol. 11, pp.80-88, 2006.

Alcázar R., Marco F., Cuevas J.C., Patron M., Ferrando A., Carrasco P., Tiburcio A.F., and Altabella T., “Involvement of polyamines in plant response to abiotic stress”, Biotechnol Lett, vol. 28, pp.1867-1876, 2006.

Sfichi L., Ioannidis N., and Kotzabasis K., “Thylakoid-associated polyamines adjust the UV-B sensitivity of the photosynthetic apparatus by means of light- harvesting complex II changes”, Photochem Photobiol, vol. 80, pp.499-506, 2004.

Zhang R.H., Li J., Guo S.R., and Tezuka T., “Effects of exogenous putrescine on gas exchange characteristics & chlorophyll fluorescence of NaCl-stressed cucumber seedlings”, Photosynth Res, vol. 100, pp.155-162, 2009.

Cook D., Flower S., Fiehn O., and Thomashow M.F., “A prominent role for the CBF cold response pathway in configuring the low temperature metabolome of Arabidopsis”, Proc Natl Acad Sci, vol. 101, pp.15243-15248, 2004.

Cuevas J.C., Lopez-Cobollo R., Alcazar R., Zarza X., Koncz C., Altabella T., Salinas J., Tiburcio A.F., and Ferrando A., “ Putrescine is involved in Arabidopsis freezing tolerance & cold acclimation by regulating abscisic acid levels in response to low temperature”, Plant Physiol, vol. 148, pp.1094-1105, 2008.

Vogel J.T., Zarka D.G., Van Buskirk H.A., Fowler S.G., and Thomashow M.F., “Roles of the CBF2 & ZAT12 transcription factors in configuring the low temperature transcritome of Arabidopsis”, Plant J, vol. 41, pp.195-211, 2005.

Anitha M. and Kavitha S., “Heavy metal & mineral element-induced abiotic stress in rice plant”, DOI:10.5772/intechopen.76080, 2018.

Sandalio L.M., Dalurzo H.C., Gomez M., Romero Puertas M.C., and del Rio L.A., “Cadmium-induced changes in the growth & oxidative metabolism of pea plants”, J Exp Bot, vol. 52, pp.2115-2126, 2001.

Groppa M.D., Benavides M.P., and ML Tomaro M.L., “Polyamine metabolism in sunflower & wheat leaf discs under cadmium or copper stress”, Plant Sci, vol. 164, pp.293-299, 2003.

Lin C.H. and Kao C.H., “Excess copper induces an accumulation of putrescine in rice leaves”, Bot Bull Acad Sin, vol. 40, pp.213-218, 1999.

Groppa M.D., Tomaro M.L., and Benavides M.P., “Polyamines as protectors against cadmium or copper-induced oxidative damage in sunflower leaf discs”, Plant Sci, vol. 161, pp481-488, 2001.

Rao M.V., Koch J.R., and Davis K.R., “Ozone: a tool for probing programmed cell death in plants”, Plant Mol Biol, vol. 44, pp.345-358, 2000.

Baier M., Kandlbinder A., Golldack D., and Dietz KJ., “Oxidative stress & ozone: perception, signaling & response”, Plant cell Environ, vol. 28, pp.1012-1020, 2005.

Van Buuren M.L., Guidi L., Fornale S., Ghetti F., Franceschetti M., Soldatini G.F., and Bagni N., “Ozone response mechanisms in tobacco: implications of polyamine metabolism”, New Phytol, 1vol. 56, pp.389-398, 2002.

Smith J., Burrit D., and Bannister P., “Ultraviolet-B radiation leads to a reduction in free polyamines in Phaseolus vulgaris L”, Plant Growth Regul, vol. 35, pp.289-294, 2001.

Zacchini M. and de Agazio M., “Spread of oxidative damage & antioxidative response through cell layers of tobacco callus after UV-C treatment”, Plant Physiol Biochem, vol. 42, pp.445-450, 2004.

An L.Z., Liu G.X., Zhang M.X., Chen T., Liu Y.H., Feng H.Y., Xu S.J., Qiang W.Y., and Wang X.L., “ Effect of enhanced UV-B radiation on polyamine content & membrane permeability in cucumber leaves”, Russ J Plant Physiol, vol. 51, pp.658-662, 2004.

Lutz C., Navakoudis E., Seidlitz H.K., and Kotzabasis K., “Simulated solar irradiation with enhanced UV-B adjust plastid & thylakoid associated polyamine changes for UV-B protection”, Biochim Biophys Acta, vol. 1710, pp.24-33, 2005.

Kim T.E., Kim S.K., Han T.J., Lee J.S., and Chang S.C., “ABA & polyamines act independently in primary leaves of cold-stressed tomato (Lycoperscion esculentum)”, Physiol Plant, vol.115, pp.370-376, 2002.

Nayyar H., “Putrescine increases floral retention, pod set & seed yield in cold stressed chickpea”, J Agron Crop Sci, vol. 191, pp.340-345, 2005.

He L., Nada K., and Tachibana S., “Effects of Spermidine pretreatment through the roots on growth and photosynthesis of chilled Cucumber plants (Cucumis sativus L)”, J Jpn Soc Hort Sci, vol. 71, pp.490-498, 2002.

Savatin D.V., Gramegna G., Modesti V., and Cervone F., “Wounding in the plant tissue: the defense of a dangerous passage”, Frontiers in Plant Science, vol. 5, pp.1-11, 2014.

Bonaventure G. and Baldwin T., “Transduction of wound & herbivory signals in plastids”, Common Integer Biol, vol. 3, pp.313-317, 2010.

Chattopadhyay M.K., Tiwari B.S., Chattopadhyay G., Bose A., Sengupta D.N., and Ghosh B., “Protective role of exogenous polyamines on salinity stressed rice (Oryza sativa) plant”, Physiol Plant, vol. 116, pp.192-199, 2002.

Yamasaki H. and Cohen M.F., “NO signal at the crossroads: Polyamine induced nitric oxide synthesis in plants”, Trends Plant Sci, vol. 11, pp.522-524, 2006.

Apel H. and Kirt H., “Reactive oxygen species: metabolism, oxidative stress & signal transduction”, Annu Rev Plant Biol, vol. 55, pp.373-379, 2004.

Roy P., Niyogi K., Sen Gupta D.N., and Ghosh B., “Spermidine treatment to rice seedlings recover salinity stress-induced damage of plasma membrane & PM-bound H+ ATPase in salt tolerant & salt sensitive rice cultivars”, Plant Sci, vol. 168, pp.583-91, 2005.

Bassie L., Zhu C., Romagosa I., Christou P., and Capell T., “Transgenic wheat plants expressing an oat arginine decarboxylase cDNA exhibit increases in polyamine content in vegetative tissue & seeds”, Mol Breed, vol. 22, pp.39-50, 2008.

Wang J., Sun P.P., Chin C.L., Wang Y., Fu X.Z., and Liu J.H., “An arginine decarboxylase gene AtADC from Poncirus trifoliata confers abiotic stress tolerance & promotes primary root growth in Arabidopsis”, J Exp Bot, vol. 62, pp.2899-2914, 2011b.

Waie B. and Rajma M.V., “Effect of increased polyamine biosynthesis on stress response in transgenic tobacco by introduction of human S-adenosylmethionine gene”, Plant Sci, vol. 164, pp.727-734, 2003.

Tiburcio A.F., Wollenweber B., Zilberstein A., and Koncz C., “Abiotic stress tolerance”, Plant Sci, vol. 182, pp.1-2, 2012.

Zhao L-L., Song S-Q., You C-X., Moriguchi T., and Hao Y-J., “Functional characterization of the apple MdSAMDC2 gene by ectopic promoter analysis & overexpression in tobacco”, Biol Plant, vol. 54, pp.631-638, 2010.

Xu Y., Shi G.X., Ding C.X., and Xu X.Y., “Polyamine metabolism & physiological responses of Potamogeton crispus leaves under lead stress”, Russ J Plant Physiol, vol.58, pp.460-6, 2011.

Roy M., and We R., “Arginine decarboxylase transgene expression & analysis of environmental stress tolerance in transgenic rice”, Plant Sci, vol. 160, pp.869-75, 2001.

Cheng L., Zou Y., Ding S., Zhang J., Yu X., Cao J., and Lu G., “Polyamine accumulation in transgenic tomato enhances the tolerance to high temperature stress”, J Integer Plant Biol, vol. 51, pp.489-499, 2009.

Wen X-P., Pang X-M., Matsuda N., Kita M., Inow H., Hao Y-J., Honda C., and Moriguchi T., “ Overexpression of the apple spermidine synthase gene in pear confers multiple abiotic stress tolerance by altering polyamine titers”, Transgenic Res, vol.17, pp.251-263, 2008.




How to Cite

Aktar, F. ., Islam, M. S., Milon, M. A.-A. ., Islam, N., & Islam, M. A. (2021). Polyamines: An Essentially Regulatory Modulator of Plants to Abiotic Stress Tolerance: A Review. Asian Journal of Applied Sciences, 9(3). https://doi.org/10.24203/ajas.v9i3.6634