The Relationship of Birth Weight Infant with Bacteriological Profile and Antibiotic Resistance of Neonatal Sepsis

Authors

  • Nisrina Asysyifa Health Polytechnic of Jakarta III Jakarta, Indonesia)
  • Husjain Djajaningrat
  • Diah Lestari

DOI:

https://doi.org/10.24203/ajas.v7i5.5932

Keywords:

Birth Weight Infant, Neonatal Sepsis, Bacteriological Profile, Antibiotic Resistance

Abstract

Neonatal sepsis is a major issue on neonatal-care field. This incident occurs by many factors, one of the factor is infant with a low birth weight. Blood culture is used as the gold standard for diagnosis. The spectrum of bacteria which caused neonatal sepsis is constantly change and vary due to antibiotic resistance phenomenon. This study aimed to determine the relationship of birth weight infant with bacteriological profile and antibiotic resistance of neonatal sepsis in RSAB Harapan Kita Jakarta. This study used observational method with cross sectional design and purposive sampling method which is analyzed by chisquare test. Medical record data and blood culture and antibiotic resistance test from all subjects in Januari until December 2018 were reviewed. The sample in this research is neonatal sepsis patients who met inclusion criteria were 51 patients. From 51 (55,43%) subjects, there were 39 (76,47%) neonatal sepsis in low birth weight infant. Klebsiella pneumonia spp (41,17%) and Staphylococcus epidermidis (19,60%) were the predominant pathogens. Amikacin (62,74%), and meropenem (50,98%) were the most susceptible antibiotic towards bacteria. Maximum resistance among organisms was seen in cefotaxime (84,31%), ceftazidime (78,43%), and amoxicillin (70,58%).  The result of the analysis found there is a relationship between birth weight infant and bacteriological profile (p-value = 0,035), but there is no relationship between birth weight infant and antibiotic resistance of neonatal sepsis (p-value =0,092; 0,066; and 0,521). There is a relationship between birth weight infant and bacteriological profile , but there is no relationship between birth weight infant and antibiotic resistance of neonatal sepsis.

Author Biography

Nisrina Asysyifa, Health Polytechnic of Jakarta III Jakarta, Indonesia)

Medical Technic Laboratory

References

Oyong, N., Anggraini, D. and Karina. 2016. Pola Resistensi Bakteri Penyebab Sepsis Neonatorum di Instalasi Perawatan Neonatus RSUD Arifin Achmad Riau. Sari Pediatri. Vol 17 No 6.

Depkes RI. 2007. Penatalaksanaan Sepsis Neonatorum. Departemen Kesehatan Republik Indonesia: Jakarta.

Wilar, R. et al. 2016. A comparison of neutrophil gelatinase-associated lipocalin and immature to total neutrophil ratio for diagnosing early-onset neonatal sepsis. Paediatrica Indonesiana. Vol 56 No 2: 107-110.

Brooks, G. et al. 2012. Mikrobiologi Kedokteran Jawetz, Melnick, & Adelberg. 25th edn. EGC: Jakarta.

Sianturi, P. et al. 2012. Profil Sepsis Neonatus di Unit Perawatan Neonatus RSUP H Adam Malik Medan Tahun 2008-2010. Sari Pediatri. Vol 14 No 2: 67–72.

Norma, N. dan Mustika, D. 2013. Asuhan Kebidanan Patologi Teori dan Tinjauan Kasus Dilengkapi Contoh Askeb. Yogyakarta: Nuha Medika.

Simbolon, D. 2008. Faktor Risiko Sepsis pada Bayi Baru Lahir di RSUD Curup Kabupaten Rejang Lebong. Buletin Penelitian Kesehatan. Vol 36 No 3: 127-134.

Juniatiningsih, A., Aminullah, A. dan Firmansyah, A. 2008. Profil Mikroorganisme Penyebab Sepsis Neonatorum di Departemen Ilmu Kesehatan Anak Rumah Sakit Cipto Mangunkusumo Jakarta. Sari Pediatri. Edisi Juni 2008. Vol 10 No 1: 60-65.

Rasyidah. 2014. Pola Kuman dan Uji Kepekaan Antibiotik pada Sepsis Neonatorum di Unit Perawatan Neonatus RSUD dr Pirngadi Kota Medan. Sari Pediatri. Vol 3 No 1: 431–436.

Hayatullah, M. K. et al. 2017. Terapi Antibiotika Empiris pada Neonatus. Journal of Medical School University of Sumatera Utara. Edisi Juni 2017. Vol 50 No.2: 107-110.

Edy, Ferdy dan Latre. 2007. Pola Mikroorsganisme dan Sensitivitas dari Spesimen Klinik di UPIN dan “Intermediate wardâ€s. Sari Pediatri. Edisi. Juni 2007. Vol 9 No 1: 67–74.

Djajakusli, S. et al. 2017. Profil Kematian Neonatus di RSUD dr. Soetomo. Jurnal Ilmu Kesehatan Anak. Vol 18 No 6: 474.

Nasution, D. A. 2008. Faktor Risiko dan Kesamaan Jenis Bakteri Jalan Lahir Ibu dengan Kultur Darah pada Sepsis Neonatal Awitan Dini. Thesis. Jurusan Sains Biomedis Universitas Diponegoro. Semarang.

Tavora AC, et al. 2008. Risk Factors for Nosocomial Infection in a Brazilian Neonatal Intensive Care Unit. The Brazilian Journal of Infectious Diseases. Vol 12 No 1: 75–79.

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Published

2019-10-21

How to Cite

Asysyifa, N., Djajaningrat, H., & Lestari, D. (2019). The Relationship of Birth Weight Infant with Bacteriological Profile and Antibiotic Resistance of Neonatal Sepsis. Asian Journal of Applied Sciences, 7(5). https://doi.org/10.24203/ajas.v7i5.5932