Effect of Iron Overload and Lipid Peroxidation on Hyroid Function in Iraqi Patients with ÃŸ- Thalassemia
Keywords:beta-thalassemia, serum ferritin, MDA, hypothyroidism
Background: Iron overload due to blood multi transfusion can lead to thyroid dysfunction in beta-thalassemia major patients with increased cell damage due to imbalance of the redox system .An iron chelation is essential to prevent the deposition of iron in tissues and glands such as thyroid.
Objectives: to investigate the reflections of blood transfusion induced iron overload and lipid peroxidation on the status of thyroid functions in Iraqi children and young adults with beta-thalassemia major.
Methods: Blood samples were taken from 60 males & females with Beta thalassemic major (BTM ) with age ranged (3-32) years. An automated hematology analyzer (Sysmex) was used in the measurements of blood Hb concentration and red cell indices. malondialdehyde(MDA), serum iron and total iron binding capacity (TIBC) concentration were determined spectrophotometrically . The triiodotyronine (T3) ,Free T3,thyroxine (T4),Free T4 ,thyroid stimulating hormone (TSH) and Serum Ferritin concentrations were assayed by an ELISA method .
Results : There were Â low mean concentration Â of Â Hb Â in Â BTM Â and a significant Â increase in serum ferritin and MDA Â in Â comparison Â with Â the Â normal Â corresponding Â values Â forÂ the Â control Â . Hypothyroidism was found in 12 (20%) out of 60 patients with BT major, (12%) were having subclinical hypothyroidism and five (8%) suffer from primary hypothyroidism with a positive a correlation of serum ferritin concentration with both MDA and number of monthly transfused blood units.
Conclusion: Transfusion associated iron overload play an effect on lipid peroxidation and the thyroid hormones (T3, T4) metabolism which leads to a disturbance in thyroid hormones secretion as consequences of thyroid dysfunction.
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