Optimizing Ethanol Production in a Microbial Fermentation Model Using an On-Off Feeding Strategy
Keywords:fermentation system, optimal control, hybrid gradient-based numerical method
In a fermentation process, the amount and appropriate timing of feeding nutrient are very essential parameters for achieving efficiency and productivity. In this study, we propose an on-oï¬€ strategy of feeding glucose for the yeast cell and apply an optimal control theory to ï¬nd an optimal feeding rate and feeding time to produce a high ethanol production. Using a gradient-based method we solve an optimization problem subjected to a state system constrain and an inequality stability constrain. We ï¬nd the following feeding strategies: for feeding with shorter delay requires lower glucose supply whereas for longer one it requires higher supply.
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