Evaluation of the Teratogenic Potentials of Muscle Relaxant Myolgin in Albino Rats
Abstract
Abstract
Teratology is the study of abnormal development in embryos, and the causes of congenital malformation or birth defects.
Musculoskeletal conditions are very common to cause tenderness and muscle spasms as fibromyalgia, tension headaches, myofascial pain syndrome, and mechanical low back or neck pain. Skeletal muscle relaxants are one of several classes of medications such as anti-inflammatory drugs and pain relievers that are used to treat these conditions. However insufficient information is available regarding its safety during pregnancy. Therefore, this work was initiated to study the effect of prenatal exposure of mylogine on fetuses of female rats. The study was conducted on pregnant rats to observe the safety profile of mylogine in comparison to control. Pregnant albino rats (Rattus norvegicus) were administrated during organogenesis period with therapeutic dose. Fetuses were removed from the uterus and evaluated for mortality rate, growth parameters, morphological and skeletal malformation as well as histological study of liver, kidney and brain. Results showed significant reduction in placental weight of pregnant rats treated with mylogine. Fetal growth retardation during gestational period was recorded also some skeletal anomalies were observed. These abnormalities included weak ossification of the skull bones roof and bones forming girdles and limbs. Histopathological studies of fetuses during gestation revealed changes in liver histology such as presences of clumping of the hepatocytes with hyperchromatic nuclei and increases in the number of megakaryocytes were seen, kidney tissue revealed numbers of mitotic activity in the nuclei of the tubular lining epithelium, coagulative necrosis in the lining tubular epithelium of the proximal convoluted tubules at the cortex and the cerebrum showed severe congestion in the meningeal blood vessels. Our findings suggest the need for great caution to handle mylogine especially during pregnancy.
Key words: Muscles relaxants, Teratogenicity, Gestation and Albino Rats.References
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