Evaluation of Different Particle Size Reduction Techniques in Application of Formulation Preparation


  • Darrin Lau University of California, Berkeley Berkeley, CA 94720
  • Minli Xie Small Molecule Technical Operation, Medivation, 525 Market St #36
  • Yingqing Ran Small Molecule Pharmaceutical Sciences, Genentech DNA Way,


Particle size, size reduction, Avicel PH 101, Naproxen, Dibasic calcium phosphate dihydrate


Several commonly used particle size reduction techniques were evaluated in this study.  Two excipients Avicel PH 101, calcium phosphate dihydrate and a poorly soluble compound naproxen were used for evaluation. All the techniques tested in this study: tissue grinder, glass beads, Glen Mills high speed mixer, polytron and sonication showed different degree of particle size reduction. The polytron in combination with the sonicator proved to be the most suitable technique for particle size reduction in discovery with limited API available. The processed particle sizes from the polytron technique were comparable to the glass tissue grinders while minimizing the loss of sample. Glass beads created small particle sizes (under 20 microns) depending on the length of time, but it was overly time consuming. Glen-mill needs about hundreds of milligram material to work with despite the comparable particle size reduction.


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How to Cite

Lau, D., Xie, M., & Ran, Y. (2016). Evaluation of Different Particle Size Reduction Techniques in Application of Formulation Preparation. Asian Journal of Applied Sciences, 4(4). Retrieved from https://ajouronline.com/index.php/AJAS/article/view/3999