Deleterious Morphological Changes and Hormonal Profile Induced by Tetracycline on the Male Accessory Organs of Adult Male Wistar Rats
Keywords:Tetracycline, Testosterone, Testis, Prostate, Seminal vesicle
Tetracycline (TET) is a popular broad spectrum antibiotics known to man for treating infections mainly bacterial for many years now. However, due to paucity of knowledge; we aim to study its impact and mechanism on the male reproductive organs of treated Wister rats using histomorphometric and hormonal analysis methods.
Twenty-one adult male Wister rats with average weight of 135g were divided into three groups. Two treated groups received a daily oral dose of TET at 2.0 mg/kg bwt and 4.0mg /kg bwt respectively via gastric gavage, while equal volume of normal saline was administered to the control group for five weeks. The result showed that TET administration caused a significant reduction in the testosterone level, as well as induction of adverse histo-pathologic changes in the testes. However, there was a significant increase (P<0.05) in the weights of the male accessory sex glands-( prostate and seminal vesicles) as compared to the control animals in a dose- dependent manner. Hence, we concluded that TET administration is deleterious on male accessory organs with mechanisms associated with Testosterone imbalance probably at HPT-axis level.
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