Elevated Body Mass Index and Serum Resistin are Associated with Severity of Allergic Rhinitis


  • Maha M. Saber
  • Eitedal M. Daoud
  • Read M. Daoud
  • Khaled G. Abdel-Wahhab
  • Lobna Saber
  • Hanan Ez Elarab
  • Moetazza M. Alshafei


allergic rhinitis (AR), body mass index(BMI), immunoglobulin E, total nasal symptom score (TNSS), resistin


Background: Allergic rhinitis is a prevalent chronic respiratory problem that can impair quality of life, sleep and work. The increase in the prevalence of allergic rhinitis among the general population appears to have an association with weight. Obese individuals are more vulnerable to allergy. Resistin, a recently discovered adipokine, has been shown to have pro-inflammatory properties in humans. This study was designed to evaluate the body mass index of patients with allergic rhinitis and their serum resistin levels and to investigate their association with clinical disease severity.

Methods: A case-controlled study was performed on 34 with persistent allergic rhinitis and 20 healthy controls with similar age and sex. Anterior  rhinoscopy was done for all patients. Blood samples were collected from the patients for analysis including: total serum immunoglobulin E (IgE) cortisol and resistin. Each patient completed a questionnaire assessment to evaluate the severity of allergic symptoms including nasal obstruction, sneezing, rhinorrhea, and itchy nose. Height and weight were measured by a trained researcher.

Results: Body mass index and serum levels of resistin were significantly increased in patients with allergic rhinitis compared with controls, and both correlated positively with disease severity. In addition, they correlated positively with nasal symptom scores. A significant positive correlation was observed between serum levels of resistin with both IgE and body mass index.

Conclusions: Patients with allergic rhinitis persistent were found to have higher body mass index and serum levels of resistin, and their levels increased with the progress of disease severity. Resistin may represent a novel link between inflammation and allergic rhinitis .Weight control should be considered as a potential strategy to improve the health status of patients with allergic rhinitis, through the control of symptoms and the improvement of general health.


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How to Cite

Saber, M. M., Daoud, E. M., Daoud, R. M., Abdel-Wahhab, K. G., Saber, L., Elarab, H. E., & Alshafei, M. M. (1). Elevated Body Mass Index and Serum Resistin are Associated with Severity of Allergic Rhinitis. Asian Journal of Applied Sciences, 3(5). Retrieved from https://ajouronline.com/index.php/AJAS/article/view/3278

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