Efficacy study of Indigenous Probiotics for Treatment of Acute Diarrhea in Infants: A Double- Blind, Placebo-Controlled Study
Keywords:
indigenously isolated probiotics, acute diarrhea, multistrain probiotics, Double- blind, Placebo-controlled clinical trial, recovery timeAbstract
Double- blind, Placebo-controlled clinical trial was conducted to study the efficacy of three indigenous probiotics in the treatment of acute diarrhea in infants. Pateints were catedorized by ages ( birth to 6 months and 6 to 12 months) and observed daily for number of stools per day, vomiting episodes, loss of weight, and recovery days from diarrhea. In first category, the majority of patients were normalized in 16±2.7 days after intaking Lactobacillus-formula, while took 11±1.9 days in the case of Bifido-fromula. Minimum number of days were calculated for the recovery of patients in the Mixed-formula (04±1.2 days). While the controlled group recovered in 21±4 days. In second category, a significantly late recovery response was observed in the controlled group (28±1.3 days) while Mixed formula again proved to be the best formula with only 08±2.2 recovery days in major cases with significant value of 3.4±1.4 mean number of stool per day, 0.9±0.3 mean vomiting episodes per infant, and 0.5±1.1 mean loss in weight per infant. The results revealed that these indigenously isolated probiotics, especially in the mixed multistrain cultures are effective in treatment of acute diarrhea in infants.
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